Technology Process of C16H16F3N3O4
There total 1 articles about C16H16F3N3O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-α-trifluoroacetyl-L-histidine methyl ester;
With
trifluoroacetic acid;
In
dichloromethane;
for 0.0833333h;
4-methoxyphenylboronic acid;
With
ammonium persulfate; silver nitrate;
In
dichloromethane; water;
at 20 ℃;
regioselective reaction;
DOI:10.1039/c4md00041b
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride; water / Reflux
2: sodium hydroxide / water; 1,4-dioxane / 12 h / 20 °C / pH 12
3: N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide / 60 °C / Microwave irradiation
4: hydrogenchloride; water / 0.25 h / 25 °C
With
hydrogenchloride; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; diisopropyl-carbodiimide;
In
1,4-dioxane; water;
DOI:10.1039/c4md00041b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; water / Reflux
2.1: sodium hydroxide / water; 1,4-dioxane / 12 h / 20 °C / pH 12
3.1: diisopropyl-carbodiimide; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide / N,N-dimethyl-formamide / 0.08 h / Microwave irradiation
3.2: 0.42 h / 60 °C
With
hydrogenchloride; endo-N-hydroxy-5-norbornene-2,3-dicarboxyimide; water; sodium hydroxide; diisopropyl-carbodiimide;
In
1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1039/c4md00041b
