(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

Base Information

Chemical Name:(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid
CAS No.:1919888-06-4
Molecular Formula:C₂₄H₂₆ClF₂N₅O₂
Molecular Weight:489.953
Hs Code.:

(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

Synonyms:

Suppliers and Price of (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
LY3295668 99.61%
100mg
$ 4500.00

ChemScene
LY3295668 99.61%
50mg
$ 2950.00

ChemScene
LY3295668 99.61%
10mg
$ 950.00

ChemScene
LY3295668 99.61%
5mg
$ 650.00

Total 11 raw suppliers

Chemical Property of (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

Chemical Property:

Boiling Point:631.2±55.0 °C(Predicted)
Density:1.390±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

LY3295668 99.61% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

There total 12 articles about (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylate

: 1919888-06-4
(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

Guidance literature:: With hydrogenchloride; In water; at 93 - 96 ℃; for 17h;

Reference yield:

: methyl 1-[(3-chloro-2-fluorophenyl)methyl]-2-methyl-piperidine-4-carboxylate

: 1919888-06-4
(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: SEC-BUTYLAMINE; isopropylamine / isopropyl alcohol / 35 °C / Supercritical conditions; Resolution of racemate

2.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 78 h / 70 °C / Reflux

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3.2: 5 - 20 °C / Cooling with ice

4.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 - -71 °C

4.2: 2 h / -78 - -71 °C

5.1: hydrogenchloride / 1,4-dioxane / 25 h / 20 - 50 °C

6.1: potassium carbonate / acetonitrile / 0.33 h / 20 °C

6.2: 72 h / 20 °C

7.1: palladium diacetate; tert-butyl XPhos; caesium carbonate / tert-butyl alcohol / 5.5 h / 40 - 100 °C / Inert atmosphere

8.1: hydrogenchloride / water / 17 h / 93 - 96 °C

With hydrogenchloride; SEC-BUTYLAMINE; carbonochloridic acid 1-chloro-ethyl ester; palladium diacetate; potassium carbonate; caesium carbonate; isopropylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane; isopropyl alcohol; acetonitrile; tert-butyl alcohol;

Reference yield:

: methyl (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-2-methyl-piperidine-4-carboxylate

: 1919888-06-4
(2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methylpiperidine-4-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 78 h / 70 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.2: 5 - 20 °C / Cooling with ice

3.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 2 h / -78 - -71 °C

3.2: 2 h / -78 - -71 °C

4.1: hydrogenchloride / 1,4-dioxane / 25 h / 20 - 50 °C

5.1: potassium carbonate / acetonitrile / 0.33 h / 20 °C

5.2: 72 h / 20 °C

6.1: palladium diacetate; tert-butyl XPhos; caesium carbonate / tert-butyl alcohol / 5.5 h / 40 - 100 °C / Inert atmosphere

7.1: hydrogenchloride / water / 17 h / 93 - 96 °C

With hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; palladium diacetate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; tert-butyl XPhos; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile; tert-butyl alcohol;