2-methoxy-5-methyl-1,4-benzenediol diacetate

Base Information

• Chemical Name: 2-methoxy-5-methyl-1,4-benzenediol diacetate
• CAS No.: 100118-34-1
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol file: 100118-34-1.mol

Synonyms:

Chemical Property of 2-methoxy-5-methyl-1,4-benzenediol diacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-5-methyl-1,4-benzenediol diacetate

There total 5 articles about 2-methoxy-5-methyl-1,4-benzenediol diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

p-methylanizole (104-93-8) + acetic acid (64-19-7,77671-22-8) → 2-methoxy-5-methyl-1,4-benzenediol diacetate (100118-34-1)

Guidance literature:

With sodium nitrate; acetic anhydride; trifluoroacetic acid; at 20 ℃; for 14h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02183

Reference yield:

2,5-dihydroxy-4-methoxytoluene (7417-68-7) + 2-acetoxy-4-methoxybenzoic acid (17336-11-7) → 2-methoxy-5-methyl-1,4-benzenediol diacetate (100118-34-1)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 18h; Ambient temperature;

Reference yield:

acetic anhydride (108-24-7) + 2-methoxy-5-methyl-1,4-benzoquinone (614-13-1) → 2-methoxy-5-methyl-1,4-benzenediol diacetate (100118-34-1)

Guidance literature:

With zinc;

upstream raw materials:

acetic anhydride

2-methoxy-5-methyl-1,4-benzoquinone

2,5-dihydroxy-4-methoxytoluene

2-acetoxy-4-methoxybenzoic acid

Refernces

• 1、 Burke, John M.,Stevenson, Robert. "Natural Benzofurans. Synthesis of Methylsainfuran and Sainfuran". . p. 1577 - 1584. Retrieved 2007/10/02.