17336-11-7

Upstream product

• 2237-36-7 4-methoxysalicylic acid 
• 108-24-7 acetic anhydride 
• 75-36-5 acetyl chloride 
• 89512-39-0 4',7-dimethoxyflavylium chloride 
• 24533-04-8 2-acetoxy-4,4'-dimethoxychalcone 
• 89475-36-5 3',4'-dihydroxy-7-dimethoxyflavylium chloride 
• 89475-37-6 2,3',4'-Triacetoxy-4-methoxy-chalkon 

Downstream Products

• 19202-27-8 2-acetoxy-4-methoxy-benzoyl chloride 
• 100118-34-1 2-methoxy-5-methyl-1,4-benzenediol diacetate 
• 2237-36-7 4-methoxysalicylic acid 
• 108980-49-0 4'-Methyl-7-Methoxyflavone 
• 22395-22-8 7-methoxoyflavone 
• 1403475-71-7 5-methoxy-2-(3-p-tolylpropioloyl)phenyl acetate 
• 1403475-70-6 5-methoxy-2-(3-phenylpropioloyl)phenyl acetate 
• 1260224-79-0 C₂₇H₂₄ClNO₅ 
• 1260224-80-3 4-chloro-3'-((2-cyclopentyl-3-oxo-2,3-dihydrobenzo[d]isoxazol-6-yloxy)methyl)biphenyl-3-carboxylic acid 
• 1260224-77-8 N-cyclopentyl-N,2-dihydroxy-4-methoxybenzamide 
• 221360-82-3 (S)-N-[5-(4-Methylpiperazin-1-yl)-3,4-dihydro-2H-1-benzopyran-3-yl]-2-hydroxy-4-methoxybenzamide 
• 500891-55-4 6-methoxy-benzofuran-3-ol 
• 131632-63-8 1-[1-(2-Acetoxy-4-methoxybenzoyl)-4-piperidinyl]-3,4-dihydrocarbostyril 
• 131633-19-7 1-{1-[2-(3-Hydroxypropoxy)-4-methoxybenzoyl]-4-piperidinyl}-3,4-dihydrocarbostyril 

Relevant academic research and scientific papers

Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats

The modification of 3′-((2-cyclopentyl-6,7-dimethyl-1-oxo-2,3- dihydro-1H-inden-5-yloxy)methyl)biphenyl-4-carboxylic acid (BINA, 1) by incorporating heteroatoms into the structure and replacing the cyclopentyl moiety led to the development of new mGluR2 positive allosteric modulators (PAMs) with optimized potency and superior druglike properties. These analogues are more potent than 1 in vitro and are highly selective for mGluR2 vs other mGluR subtypes. They have significantly improved pharmacokinetic (PK) properties, with excellent oral bioavailability and brain penetration. The benzisothiazol-3-one derivative 14 decreased cocaine self-administration in rats, providing proof-of-concept for the use of mGluR2 PAMs for the treatment of cocaine dependence.

A New Method for the Degradation of Anthocyanidins, Flavones, Chalcones, and Coumarins

After transformation into the corresponding chalcone or flavenol acetates anthocyanidins are oxidatively cleaved with ruthenium tetroxide to yield benzoic acid derivatives of the rings A and B.Flavones, chalcones, and coumarins are degradated by the same method.