(2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one

Base Information

• Chemical Name: (2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one
• CAS No.: 402725-31-9
• Molecular Formula: C₂₄H₃₉N₃O₈Si₂
• Molecular Weight: 553.76
• Mol file: 402725-31-9.mol

Synonyms:

Chemical Property of (2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one

There total 4 articles about (2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-ol (402725-30-8) → (2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one (402725-31-9)

Guidance literature:

With PrⁱNEt; trifluoroacetic anhydride; Yield given. Multistep reaction; 1.) Me₂SO, CH₂Cl₂, -65 deg C to rt;;

DOI:10.1039/c39870000251

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → (2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one (402725-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / 1.) DMF, rt.; 2.) imidazole

2: (CF₃CO)2O, PrⁱNEt / 1.) Me₂SO, CH₂Cl₂, -65 deg C to rt;

With PrⁱNEt; sodium carbonate; trifluoroacetic anhydride;

DOI:10.1039/c39870000251

Reference yield:

2,4-Dinitrofluorobenzene (70-34-8,65727-75-5) → (2R,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-tetrahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-one (402725-31-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Na₂CO₃ / 1.) DMF, rt.; 2.) imidazole

2: (CF₃CO)2O, PrⁱNEt / 1.) Me₂SO, CH₂Cl₂, -65 deg C to rt;

With PrⁱNEt; sodium carbonate; trifluoroacetic anhydride;

DOI:10.1039/c39870000251

upstream raw materials:

(2R,3S,3aR,9aR)-2-(2,4-Dinitro-phenylamino)-5,5,7,7-tetraisopropyl-hexahydro-4,6,8-trioxa-5,7-disila-cyclopentacycloocten-3-ol

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

2,4-Dinitrofluorobenzene

(-)-(1R,2R,3S,4R)-4-amino-2,3-dihydroxy-1-(hydroxymethyl)cyclopentane

Downstream raw materials:

(1R,3R,5R)-3-[(2,4-dinitrophenyl)amino]-2,2-difluoro-5-(hydroxymethyl)cyclopentanol