Technology Process of 2-Bromo-3-methoxy-5-methyl-9-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxylic acid benzylamide
There total 10 articles about 2-Bromo-3-methoxy-5-methyl-9-oxo-6,7,8,9-tetrahydro-5H-benzocycloheptene-5-carboxylic acid benzylamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 80 percent / conc. sulphuric acid / 2.5 h / Heating
2: 81 percent / sodium, iron(III) nitrate / liquid ammonia; diethyl ether / 2.5 h / -78 °C
3: 70 percent / 1.) n-butyl-lithium/di-isopropylamine; 2.) HMPA / tetrahydrofuran / 0.25 h / -72 °C
4: 60 percent / sodium hydroxide / aq. ethanol / 18 h / Heating
5: 76 percent / polyphosphoric acid / 24 h / 45 °C
6: 76 percent / sodium hydride / toluene / 3 h / 75 °C
7: bromine / acetic acid / 0.25 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; PPA; sulfuric acid; bromine; sodium; sodium hydride; ferric nitrate; diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; ammonia; acetic acid; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 81 percent / sodium, iron(III) nitrate / liquid ammonia; diethyl ether / 2.5 h / -78 °C
2: 70 percent / 1.) n-butyl-lithium/di-isopropylamine; 2.) HMPA / tetrahydrofuran / 0.25 h / -72 °C
3: 60 percent / sodium hydroxide / aq. ethanol / 18 h / Heating
4: 76 percent / polyphosphoric acid / 24 h / 45 °C
5: 76 percent / sodium hydride / toluene / 3 h / 75 °C
6: bromine / acetic acid / 0.25 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; PPA; bromine; sodium; sodium hydride; ferric nitrate; diisopropylamine;
In
tetrahydrofuran; diethyl ether; ethanol; ammonia; acetic acid; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / 1.) n-butyl-lithium/di-isopropylamine; 2.) HMPA / tetrahydrofuran / 0.25 h / -72 °C
2: 60 percent / sodium hydroxide / aq. ethanol / 18 h / Heating
3: 76 percent / polyphosphoric acid / 24 h / 45 °C
4: 76 percent / sodium hydride / toluene / 3 h / 75 °C
5: bromine / acetic acid / 0.25 h / Ambient temperature
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; PPA; bromine; sodium hydride; diisopropylamine;
In
tetrahydrofuran; ethanol; acetic acid; toluene;
