35553-92-5

Basic information

• Product Name: ETHYL 3-METHOXYPHENYLACETATE
• Synonyms: ETHYL 3-METHOXYPHENYLACETATE;ETHYL 2-(3-METHOXYPHENYL)ACETATE;3-methoxyphenylacetic acid ethyl ester;3-Methoxybenzeneacetic acid ethyl ester;-methoxyphenylacetic acid ethyl ester
• CAS NO: 35553-92-5
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• EINECS: 252-614-5
• Mol File: 35553-92-5.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 82 °C
• Flash Point: 109-110°C/1mm
• Appearance: /
• Density: 1.062 g/cm³
• Vapor Pressure: 0.00637mmHg at 25°C
• Refractive Index: 1.497
• CAS DataBase Reference: ETHYL 3-METHOXYPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-METHOXYPHENYLACETATE(35553-92-5)
• EPA Substance Registry System: ETHYL 3-METHOXYPHENYLACETATE(35553-92-5)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 35553-92-5(Hazardous Substances Data)

Usage

General Description

ETHYL 3-METHOXYPHENYLACETATE is a chemical compound with the molecular formula C11H14O3. It is an ester, which means it is formed by the reaction of an alcohol and an organic acid. ETHYL 3-METHOXYPHENYLACETATE is commonly used as a flavoring and fragrance ingredient in various products such as perfumes, cosmetics, and food items. It has a slightly sweet, floral, and fruity scent and is often described as having a tropical or exotic aroma. ETHYL 3-METHOXYPHENYLACETATE is known for its pleasant smell and is used to enhance the sensory experience of various consumer goods.

InChI:InChI=1/C11H14O3/c1-3-14-11(12)8-9-5-4-6-10(7-9)13-2/h4-7H,3,8H2,1-2H3

Upstream product

• 529-28-2 4-iodoanisol 
• 26954-26-7 ethyl lithioacetate 
• 10365-98-7 3-methoxyphenylboronic acid 
• 623-33-6 glycine ethyl ester hydrochloride 
• 623-73-4 diazoacetic acid ethyl ester 
• 100-66-3 methoxybenzene 
• 1071-46-1 hydrogen ethyl malonate 
• 1003858-50-1 2-(3-methoxyphenyl)-5, 5-dimethyl-1,3,2-dioxaborinane 
• 616-27-3 1-chlorobutan-2-one 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 66107-33-3 3-methoxyphenyl triflate 
• 766-85-8 3-methoxy-1-iodobenzene 
• 2398-37-0 3-methoxyphenyl bromide 

Downstream Products

• 5020-41-7 2-(3-methoxyphenyl)-ethanol 
• 130754-15-3 ethyl 2-fluoro-2-(3-methoxyphenyl)acetate 
• 105166-35-6 2-(3-methoxyphenyl)propanoic acid ethyl ester 
• 877814-98-7 ethyl 2-(2-chlorosulfonyl-5-methoxy-phenyl)acetate 
• 25226-97-5 3-methoxyphenethyl iodide 
• 52831-89-7 5-(3-methoxy-phenyl)-pentan-2-one 
• 73004-96-3 1-(2-chloroethyl)-3-methoxybenzene 
• 2146-60-3 ethyl 2-acetyl-4-(3-methoxyphenyl)butanoate 
• 765302-50-9 ethyl 4-acetyl-3-methoxyphenylacetate 
• 50874-07-2 2-(3-methoxyphenyl)malonic acid diethyl ester 
• 1233390-33-4 (S)-5-carboxymethyl-3-(3-methoxyphenyl)tetramic acid 
• 66162-87-6 2-(3-hydroxybenzyl)-1-methylpyrrolidine 
• 66163-19-7 1-methyl-2-(3-pivaloyloxybenzyl)pyrrolidine 

Relevant articles and documents

Photoassisted Cross-Coupling Reaction of α-Chlorocarbonyl Compounds with Arylboronic Acids

A Suzuki-Miyaura cross-coupling reaction of α-chloroacetates or α-chloroacetamides with arylboronic acids is made possible by visible-light irradiation. This reaction provides a useful method for the synthesis of α-arylacetates and α-arylacetamides from chlorides under mild reaction conditions. An indole-3-acetic acid derivative that is the key intermediate of the plant hormone auxin can be synthesized from 1-Boc-indole in two steps by combining an iridium-catalyzed C-H borylation and a palladium-catalyzed cross-coupling reaction.

COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS

Provided are methods for treating neurological disorders using compounds of Formula (I), and pharmaceutically acceptable salts and compositions thereof.

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.