Technology Process of 10-(2,5-dioxopyrrolidin-1-yloxy)-10-oxodecanoic acid
There total 1 articles about 10-(2,5-dioxopyrrolidin-1-yloxy)-10-oxodecanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-hydroxy-pyrrolidine-2,5-dione; 1,10-decanedioic acid;
With
dicyclohexyl-carbodiimide;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
With
dmap;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 7h;
DOI:10.1039/b906458c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / water; N,N-dimethyl-formamide / pH 9
1.2: 18 h / Inert atmosphere
2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 64 h / 0 - 20 °C / Inert atmosphere
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine;
In
water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/b906458c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / water; N,N-dimethyl-formamide / pH 9
1.2: 18 h / Inert atmosphere
2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 64 h / 0 - 20 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 4 h / Inert atmosphere
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1039/b906458c
