(15R)-9,11-Dibenzyl-12-epi-PGF_2β

Base Information

Chemical Name:(15R)-9,11-Dibenzyl-12-epi-PGF_2β
CAS No.:88365-30-4
Molecular Formula:C₃₄H₄₆O₅
Molecular Weight:534.736
Hs Code.:

(15R)-9,11-Dibenzyl-12-epi-PGF<sub>2β</sub>

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (15R)-9,11-Dibenzyl-12-epi-PGF_2β

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Technology Process of (15R)-9,11-Dibenzyl-12-epi-PGF_2β

There total 17 articles about (15R)-9,11-Dibenzyl-12-epi-PGF_2β which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 36969-89-8
dimethyl 2-oxoheptylphosphonate

: 88365-30-4
(15R)-9,11-Dibenzyl-12-epi-PGF_2β

Guidance literature:: Multi-step reaction with 8 steps

1: 1) NaH (80percent in oil) / 1) anh. DME, r. t., 1 h, 2) DME, 40 deg C, 4 h

2: 93 percent / pyridine / 1) 1 h, 0 deg C, 2) 1 h, r. t.

3: 52 percent / ZnCl₂; NaBH₄ / 1,2-dimethoxy-ethane / 1) 1.5 h, -20 deg C, 2) 1 h, 0 deg C, 3) 3 h, r. t.

4: 2percent p-toluenesulfonic acid / CH₂Cl₂; tetrahydrofuran / 3 h / Ambient temperature

5: K₂CO₃ / methanol / 2.5 h / 35 °C

6: pyridinium-chlorochromate/Al₂O₃, anh. Na-acetate / CH₂Cl₂ / 3 h / Ambient temperature

7: 1) K-tert-butylate / 1) anh. THF, r. t., 30 min, 2) anh. THF, 5 min, -78 deg C; 40 min, 0 deg C

8: acetic acid; H₂O; tetrahydrofuran / 5 h / 40 °C

With aluminum oxide; sodium tetrahydroborate; potassium tert-butylate; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid;
DOI:10.1002/jlac.198319831215

Reference yield:

: 100-39-0
benzyl bromide

: 88365-30-4
(15R)-9,11-Dibenzyl-12-epi-PGF_2β

Guidance literature:: Multi-step reaction with 10 steps

1: 1) NaH (80percent in oil) / 1) DMF, 0.5 h, -5 deg C, 2) 3 h, r. t.

2: 90 percent / Hg(II)-acetate, Hg(II)-oxide / H₂O; acetone / 1 h

3: 1) NaH (80percent in oil) / 1) anh. DME, r. t., 1 h, 2) DME, 40 deg C, 4 h

4: 93 percent / pyridine / 1) 1 h, 0 deg C, 2) 1 h, r. t.

5: 52 percent / ZnCl₂; NaBH₄ / 1,2-dimethoxy-ethane / 1) 1.5 h, -20 deg C, 2) 1 h, 0 deg C, 3) 3 h, r. t.

6: 2percent p-toluenesulfonic acid / CH₂Cl₂; tetrahydrofuran / 3 h / Ambient temperature

7: K₂CO₃ / methanol / 2.5 h / 35 °C

8: pyridinium-chlorochromate/Al₂O₃, anh. Na-acetate / CH₂Cl₂ / 3 h / Ambient temperature

9: 1) K-tert-butylate / 1) anh. THF, r. t., 30 min, 2) anh. THF, 5 min, -78 deg C; 40 min, 0 deg C

10: acetic acid; H₂O; tetrahydrofuran / 5 h / 40 °C

With aluminum oxide; sodium tetrahydroborate; potassium tert-butylate; mercury(II) diacetate; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; mercury(II) oxide; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; acetone;
DOI:10.1002/jlac.198319831215

Reference yield:

: 74552-31-1
(6R,7R)-(-)-7-Hydroxy-3-oxabicyclo<4.3.0>non-1-en-9-on

: 88365-30-4
(15R)-9,11-Dibenzyl-12-epi-PGF_2β

Guidance literature:: Multi-step reaction with 12 steps

1: 16 g / TEA / tetrahydrofuran / 5 h / Ambient temperature

2: 11.3 g / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

3: 1) NaH (80percent in oil) / 1) DMF, 0.5 h, -5 deg C, 2) 3 h, r. t.

4: 90 percent / Hg(II)-acetate, Hg(II)-oxide / H₂O; acetone / 1 h

5: 1) NaH (80percent in oil) / 1) anh. DME, r. t., 1 h, 2) DME, 40 deg C, 4 h

6: 93 percent / pyridine / 1) 1 h, 0 deg C, 2) 1 h, r. t.

7: 52 percent / ZnCl₂; NaBH₄ / 1,2-dimethoxy-ethane / 1) 1.5 h, -20 deg C, 2) 1 h, 0 deg C, 3) 3 h, r. t.

8: 2percent p-toluenesulfonic acid / CH₂Cl₂; tetrahydrofuran / 3 h / Ambient temperature

9: K₂CO₃ / methanol / 2.5 h / 35 °C

10: pyridinium-chlorochromate/Al₂O₃, anh. Na-acetate / CH₂Cl₂ / 3 h / Ambient temperature

11: 1) K-tert-butylate / 1) anh. THF, r. t., 30 min, 2) anh. THF, 5 min, -78 deg C; 40 min, 0 deg C

12: acetic acid; H₂O; tetrahydrofuran / 5 h / 40 °C

With aluminum oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; TEA; potassium tert-butylate; mercury(II) diacetate; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; pyridinium chlorochromate; mercury(II) oxide; zinc(II) chloride; In tetrahydrofuran; pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; acetone;
DOI:10.1002/jlac.198319831215