4-[2,2-Bis(4-fluorophenyl)ethyl]piperidine

Base Information

Chemical Name:4-[2,2-Bis(4-fluorophenyl)ethyl]piperidine
CAS No.:107071-89-6
Molecular Formula:C19H21F2N
Molecular Weight:301.379
Hs Code.:
DSSTox Substance ID:DTXSID00567067
Wikidata:Q82452852

Synonyms:4-[2,2-bis(4-fluorophenyl)ethyl]piperidine;107071-89-6;SCHEMBL7437609;DTXSID00567067;RSRJNHGJHDHEQM-UHFFFAOYSA-N

Suppliers and Price of 4-[2,2-Bis(4-fluorophenyl)ethyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-[2,2-Bis(4-fluorophenyl)ethyl]piperidine

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:301.16420600
Heavy Atom Count:22
Complexity:291

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1CC(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F

Technology Process of 4-[2,2-Bis(4-fluorophenyl)ethyl]piperidine

There total 6 articles about 4-[2,2-Bis(4-fluorophenyl)ethyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 4-[2,2-bis(4-fluorophenyl)ethylene]piperidine

: 107071-89-6
4-<2,2-bis(4-fluorophenyl)ethyl>piperidine

Guidance literature:: With palladium on activated charcoal; hydrogen; In ethanol; at 20 ℃; under 4137.29 Torr; Autoclave;
DOI:10.1016/j.ejmech.2020.112866

Reference yield:

: 131911-89-2
4-[2,2-Bis(4-fluorophenyl)ethyl]pyridine hydrochloride

: 107071-89-6
4-<2,2-bis(4-fluorophenyl)ethyl>piperidine

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 16h; under 2534.03 Torr; Ambient temperature;
DOI:10.1021/jm00114a009

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 107071-89-6
4-<2,2-bis(4-fluorophenyl)ethyl>piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium; iodine / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

1.2: 3 h / Inert atmosphere; Reflux

2.1: hydrogenchloride / ethanol; water / 12 h / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / ethanol / 20 °C / 4137.29 Torr / Autoclave

With hydrogenchloride; palladium on activated charcoal; hydrogen; iodine; magnesium; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.ejmech.2020.112866