Technology Process of (2RS,3R)-4-benzyloxy-3-methylbutan-2-ol
There total 2 articles about (2RS,3R)-4-benzyloxy-3-methylbutan-2-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -10 °C
2.1: Mg
2.2: diethyl ether / 0.83 h / 20 °C
With
oxalyl dichloride; magnesium; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
1.1: Swern oxidation / 2.1: Metallation / 2.2: Grignard reaction;
DOI:10.1002/1099-0690(200010)2000:20<3459::AID-EJOC3459>3.0.CO;2-F
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 100 percent / DMAP; Et3N / dimethylformamide / 10 h / 20 °C
2.1: 90 percent / H2 / Pd-C / ethanol / 12 h / 20 °C
3.1: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 - -10 °C
4.1: nBuLi / tetrahydrofuran; hexane / 0.33 h / -70 °C
4.2: HMPA / hexane; tetrahydrofuran / 0.17 h
5.1: 100 percent / TBAF / tetrahydrofuran / 12 h / 20 °C
6.1: Dess-Martin periodinane / CH2Cl2 / 0.67 h / 20 °C
With
dmap; n-butyllithium; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; Dess-Martin periodane; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;
1.1: Etherification / 2.1: Hydrogenolysis / 3.1: Swern oxidation / 4.1: deprotonation / 4.2: olefination / 5.1: Elimination / 6.1: Dehydrogenation;
DOI:10.1002/1099-0690(200010)2000:20<3459::AID-EJOC3459>3.0.CO;2-F
