Technology Process of <4S(4α,5α,6β)>-5-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-6-<(1R*,3S*)-3-ethyl-1-(triethylsilyloxy)pent-4-enyl>-4-methylcyclohex-2-enone
There total 8 articles about <4S(4α,5α,6β)>-5-(2-<(4S*,6R*)-6-<2-(t-butyldiphenylsilyloxy)ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl)-6-<(1R*,3S*)-3-ethyl-1-(triethylsilyloxy)pent-4-enyl>-4-methylcyclohex-2-enone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) LDA / 1.) diethyl ether, -78 deg C, 45 min, 2.) diethyl ether, -78 deg C, 10 min
2: 92 percent Turnov. / di-isopropylamine, 4-(dimethylamino)pyridine / diethyl ether / 1.) 0 deg C, 30 min, 2.) room temperature, 40 h
With
dmap; diisopropylamine; lithium diisopropyl amide;
In
diethyl ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) 1.6 M butyl-lithium / 1.) hexane, THF, -6 to 0 deg C, 1 h, 2.) 0 deg C, 20 min
2: 65 percent / 10 percent v/v aq. hydrochloric acid / diethyl ether / 26 h / Ambient temperature
3: 1.) LDA / 1.) diethyl ether, -78 deg C, 45 min, 2.) diethyl ether, -78 deg C, 10 min
4: 92 percent Turnov. / di-isopropylamine, 4-(dimethylamino)pyridine / diethyl ether / 1.) 0 deg C, 30 min, 2.) room temperature, 40 h
With
hydrogenchloride; dmap; n-butyllithium; diisopropylamine; lithium diisopropyl amide;
In
diethyl ether;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) dimethylsulfoxide, oxalyl dichloride, 2.) triethylamine / 1.) dichloromethane, -78 deg C, 20 min, 2.) -78 deg C, 20 min, --> room temperature, 30 min
2: 1.) 1.6 M butyl-lithium / 1.) hexane, THF, -6 to 0 deg C, 1 h, 2.) 0 deg C, 20 min
3: 65 percent / 10 percent v/v aq. hydrochloric acid / diethyl ether / 26 h / Ambient temperature
4: 1.) LDA / 1.) diethyl ether, -78 deg C, 45 min, 2.) diethyl ether, -78 deg C, 10 min
5: 92 percent Turnov. / di-isopropylamine, 4-(dimethylamino)pyridine / diethyl ether / 1.) 0 deg C, 30 min, 2.) room temperature, 40 h
With
hydrogenchloride; dmap; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; diisopropylamine; lithium diisopropyl amide;
In
diethyl ether;
