C₁₆H₂₂O₂S

Base Information

• Chemical Name: C₁₆H₂₂O₂S
• CAS No.: 1451195-63-3
• Molecular Formula: C₁₆H₂₂O₂S
• Molecular Weight: 278.415
• Mol file: 1451195-63-3.mol

Synonyms:

Chemical Property of C₁₆H₂₂O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₂O₂S

There total 12 articles about C₁₆H₂₂O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

C9H15Br (1451195-62-2) + sodium 4-methylbenzenesulfinate (824-79-3) → C16H22O2S (1451195-63-3)

Guidance literature:

In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1271/bbb.130243

Reference yield:

C9H16O (1451195-61-1) → C16H22O2S (1451195-63-3)

Guidance literature:

Multi-step reaction with 2 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 - 20 °C

2: N,N-dimethyl-formamide / 0 - 20 °C

With carbon tetrabromide; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1271/bbb.130243

Reference yield:

cis-(1R,2S)-1-butyryloxymethyl-2-hydroxymethylcyclopropane (133494-56-1) → C16H22O2S (1451195-63-3)

Guidance literature:

Multi-step reaction with 11 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 2 h / 20 °C

2.1: potassium carbonate; methanol / 2 h / 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C

4.1: pyridinium p-toluenesulfonate / ethanol / 60 °C

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 - 20 °C

6.1: dimethyl sulfoxide; tetrahydrofuran / 1.5 h / 0 - 20 °C

7.1: n-butyllithium / N,N,N,N,N,N-hexamethylphosphoric triamide; tetrahydrofuran / 1 h / -78 °C

7.2: -78 - 20 °C

8.1: hydrogen / hexane / 1 h / 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C

10.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.33 h / 0 - 20 °C

11.1: N,N-dimethyl-formamide / 0 - 20 °C

With 1H-imidazole; methanol; n-butyllithium; carbon tetrabromide; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1271/bbb.130243

upstream raw materials:

C₉H₁₆O

C₉H₁₅Br

sodium 4-methylbenzenesulfinate

cis-(1R,2S)-1-butyryloxymethyl-2-hydroxymethylcyclopropane

Downstream raw materials:

C₄₀H₆₂O₆SSi

C₃₃H₅₆O₄Si

C₂₇H₄₂O₄

C₂₇H₄₀O₄