{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

Base Information

Chemical Name:{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester
CAS No.:568591-24-2
Molecular Formula:C₃₂H₄₅N₅O₆
Molecular Weight:595.739
Hs Code.:

{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

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Chemical Property of {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

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Technology Process of {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

There total 9 articles about {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17329-20-3,21872-32-2,21872-33-3,42412-74-8
(R)-(+)-α-methylbenzylisocyanide

: 568591-24-2
{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: CH₂Cl₂

2: aq. LiOH / dioxane / 100 °C

3: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

4: NEt₃ / tetrahydrofuran

5: 99 percent / HCl(g) / ethyl acetate / 0 °C

6: Et₃N / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; ethyl acetate; 1: Passerini reaction;
DOI:10.1016/j.bmcl.2004.07.031

Reference yield:

: 568591-15-1
[(S)-5-tert-Butoxycarbonylamino-6-hydroxy-6-((R)-1-phenyl-ethylcarbamoyl)-hexyl]-carbamic acid benzyl ester

: 568591-24-2
{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

2: NEt₃ / tetrahydrofuran

3: 99 percent / HCl(g) / ethyl acetate / 0 °C

4: Et₃N / tetrahydrofuran

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1016/j.bmcl.2004.07.031

Reference yield:

: 568591-14-0
Benzoic acid (S)-6-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-1-((R)-1-phenyl-ethylcarbamoyl)-hexyl ester

: 568591-24-2
{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. LiOH / dioxane / 100 °C

2: 99 percent / H₂ / Pd/C / ethanol / 2068.59 Torr

3: NEt₃ / tetrahydrofuran

4: 99 percent / HCl(g) / ethyl acetate / 0 °C

5: Et₃N / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; ethyl acetate;
DOI:10.1016/j.bmcl.2004.07.031