Pyridine, 4-(bromomethyl)- (9CI)

Base Information

• Chemical Name: Pyridine, 4-(bromomethyl)- (9CI)
• CAS No.: 54751-01-8
• Molecular Formula: C6H6BrN
• Molecular Weight: 172.024
• Hs Code.: 2933399090
• Mol file: 54751-01-8.mol

Synonyms:4-(Bromomethyl)pyridine;4-Pyridylmethyl bromide;

Chemical Property of Pyridine, 4-(bromomethyl)- (9CI)

Chemical Property:

• Melting Point: 235-240℃ (DEC.)
• Boiling Point: 225.8 °C at 760 mmHg
• PKA: 4.87±0.10(Predicted)
• Flash Point: 90.3 °C
• PSA: 12.89000
• Density: 1.533 g/cm³
• LogP: 1.97650
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(BROMOMETHYL)PYRIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 4-(bromomethyl)- (9CI)

There total 7 articles about Pyridine, 4-(bromomethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromomethyl pyridine hydrobromide (73870-24-3,1119106-77-2) → 4-(bromomethyl)pyridine (54751-01-8)

Guidance literature:

With sodium hydrogencarbonate; In diethyl ether; water;

Reference yield:

picoline (108-89-4) → 4-(bromomethyl)pyridine (54751-01-8)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 2h; Heating;

Reference yield:

pyridine-4-methanol (586-95-8) → 4-(bromomethyl)pyridine (54751-01-8)

Guidance literature:

With hydrogen bromide;

DOI:10.1021/jo01098a020

upstream raw materials:

pyridine-4-methanol

picoline

pyridine-4-carboxylic acid

4-bromomethyl pyridine hydrobromide

Downstream raw materials:

{(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester

C₅₇H₅₄N₆O₆

C₆₀H₆₀N₆O₆

C₅₂H₄₂F₆N₁₀O₄

Refernces

• 1、 -. "4-methoxymethylpyridine synthesis method". Paragraph 0023; 0024; 0028; 0029; 0030; 0033; 0034. . Retrieved 2020/02/04.
• 2、 Nacsa, Eric D.,MacMillan, David W. C.. "Spin-Center Shift-Enabled Direct Enantioselective α-Benzylation of Aldehydes with Alcohols". supporting information. p. 3322 - 3330. Retrieved 2018/03/13.