(2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol

Base Information

Chemical Name:(2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol
CAS No.:869102-84-1
Molecular Formula:C₂₃H₃₀O₂Si
Molecular Weight:366.576
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol

Chemical Property:

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Technology Process of (2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol

There total 2 articles about (2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103233-24-5
(2R,4S)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-methyl-4-butanolide

: 869102-84-1
(2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: DIBAL-H / toluene / -78 °C

2: n-BuLi / tetrahydrofuran / -78 - 20 °C

3: K₂CO₃ / methanol

With n-butyllithium; diisobutylaluminium hydride; potassium carbonate; In tetrahydrofuran; methanol; toluene;
DOI:10.1055/s-2005-872657

Reference yield:

: (3R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-3-methyl-tetrahydro-furan-2-ol

: 869102-84-1
(2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran / -78 - 20 °C

2: K₂CO₃ / methanol

With n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1055/s-2005-872657

Reference yield:

: 869102-84-1
(2S,4R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-methyl-hex-5-yn-2-ol

: 869102-82-9
(R)-2-(4-Methoxy-benzyloxy)-4-methyl-6-trimethylsilanyl-hex-5-ynoic acid (E)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-1,3-dimethyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: CSA / CH₂Cl₂

2: NH₄F / methanol

3: TPAP; NMO / CH₂Cl₂ / 0 °C

4: NaClO₂; NaH₂PO₄

5: DCC; DMAP / CH₂Cl₂ / 0 °C

6: LiHMDS / -78 °C

7: AcOH / tetrahydrofuran / -78 °C

With dmap; ammonium fluoride; sodium chlorite; sodium dihydrogenphosphate; N-methyl-2-indolinone; tetrapropylammonium perruthennate; camphor-10-sulfonic acid; acetic acid; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-2005-872657