103233-24-5

Basic information

• Product Name: (2R,4S)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-methyl-4-butanolide
• Synonyms: (2R,4S)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-methyl-4-butanolide
• CAS NO: 103233-24-5
• Molecular Weight: 368.548
• Mol File: 103233-24-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (2R,4S)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-methyl-4-butanolide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-methyl-4-butanolide(103233-24-5)
• EPA Substance Registry System: (2R,4S)-4-<<(tert-butyldiphenylsilyl)oxy>methyl>-2-methyl-4-butanolide(103233-24-5)

Safety Data

• Hazardous Substances Data: 103233-24-5(Hazardous Substances Data)

Upstream product

• 56-86-0 L-glutamic acid 
• 114142-19-7 S-γ-tert-butyldiphenylsilyloxymethyl-γ-butyrolactone 
• 74-88-4 methyl iodide 
• 130606-67-6 C₁₁H₁₈O₄ 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 32780-06-6 (5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran 
• 102717-29-3 (5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one 
• 21461-84-7 (2S)-tetrahydro-5-oxofuran-2-carboxylic acid 

Downstream Products

• 1417797-17-1 (3R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-3-fluoro-3-methyldihydrofuran-2(3H)-one 
• 1313511-89-5 (5S,7R)-5-((S)-1-((4-methoxybenzyl)oxy)-2-((2R,3S)-3-vinyloxiran-2-yl)ethyl)-2,2,3,3,7,10,10,11,11-nonamethyl-4,9-dioxa-3,10-disiladodecane 
• 1313511-88-4 ((2S,3S)-3-((2S,3S,5R)-3,6-bis((tert-butyldimethylsilyl)oxy)-2-((4-methoxybenzyl)oxy)-5-methylhexyl)oxiran-2-yl)methanol 
• 1256742-41-2 C₂₅H₃₆O₃Si 
• 1519887-70-7 (1R,3S,5R,3a'S,4'S,7a'S)-3-[(tert-butyldiphenylsilyl)-oxymethyl ]4'-iodo-5,7a'-dimethyl-2,3'-dioxaspiro[cyclopentane-1,1'-hexahydroindan]-2'-one 
• 1519887-72-9 (1S,3S,5R,3a'S,4'S,7a'S)-3-[(tert-butyldiphenylsilyl)-oxymethyl ]4'-iodo-5,7a'-dimethyl-2,3'-dioxaspiro[cyclopentane-1,1'-hexahydroindan]-2'-one 
• 1519887-61-6 C₃₀H₄₀O₄Si 
• 1519887-58-1 (R)-3-methylcyclohex-2-en-1-yl (2R,3R,5S)-5-[(tert-butyldiphenylsilyl)oxymethyl]-3-methyltetrahydrofuran-2-carboxylate 
• 1519887-56-9 C₂₃H₂₉O₄Si^(1-)*K⁽¹⁺⁾ 
• 1519887-54-7 (2R,3R,5S)-5-[(tert-butyldiphenylsilyl)oxymethyl]-3-methyltetrahydrofuran-2-carbaldehyde 
• 1519887-51-4 C₂₉H₃₆O₃SSi 
• 1519887-49-0 (2S,3R,5S)-5-[(tert-butyldiphenylsilyl)oxymethyl]-3-methyl-2-(phenylthiomethyl)tetrahydrofuran 
• 1519887-63-8 C₃₀H₄₀O₄Si 
• 1256742-40-1 C₂₂H₃₂O₃Si 

Relevant articles and documents

NUCLEOTIDE AND NUCLEOSIDE THERAPEUTICS COMPOSITIONS AND USES RELATED THERETO

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.

NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO

This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses related thereto. In certain embodiments, the disclosure relates to halogenated nucleosides optionally conjugated to a phosphorus oxide or pharmaceutically acceptable salts thereof. In certain embodiments, the disclosure relates to conjugate compounds or pharmaceutically acceptable salts thereof comprising an amino acid ester or a sphingolipid or derivative linked by a phosphorus oxide to a nucleotide or nucleoside. In certain embodiments, the disclosure contemplates pharmaceutical compositions comprising these compounds for uses in treating infectious diseases, viral infections, and cancer.

2',3'-DIDEOXY-2'-α-FLUORO-2'-β-C-METHYLNUCLEOSIDES AND PRODRUGS THEREOF

The present invention provides 2',3'-dideoxy-2'-fluoro-α-2'-C- methylnucleosides, their prodrugs, and therapeutic use thereof as anti-HCV agents. The present invention also provides processes and intermediates for the preparation of the nucleosides disclosed herein.