14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Base Information

Chemical Name:14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin
CAS No.:1350636-85-9
Molecular Formula:C₃₁H₄₉NO₇S
Molecular Weight:579.799
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Chemical Property:

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Technology Process of 14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

There total 18 articles about 14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: pleuromutilin

: 1350636-85-9
14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / dichloromethane / 20.33 h / 10 - 25 °C / Reflux; Industry scale

2.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

3.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

3.2: 1.5 h / 0 - 25 °C / Industry scale

4.1: triethylamine / dichloromethane / 20 °C

With phosphoric acid; triethylamine; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In dichloromethane; tert-butyl methyl ether; water; isopropyl alcohol;

Reference yield:

: 31716-01-5
pleuromutilin tosylate

: 1350636-85-9
14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

2.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

2.2: 1.5 h / 0 - 25 °C / Industry scale

3.1: triethylamine / dichloromethane / 20 °C

With phosphoric acid; triethylamine; sodium hydroxide; benzyltri(n-butyl)ammonium chloride; In dichloromethane; tert-butyl methyl ether; water; isopropyl alcohol;

Reference yield:

: 5709-98-8
(R)-cyclohex-3-enecarboxylic acid

: 1350636-85-9
14-O-{[(1R,2R,4R)-4-ethoxycarbonylamino-2-hydroxy-cyclohexyl-sulfanyl]-acetyl}-mutilin

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.58 h / 20 - 95 °C / Reflux

2.1: copper(l) chloride / 0.83 h / 80 - 100 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3.5 h / 15 - 40 °C / Industry scale

4.1: tetrabutyl-ammonium chloride / toluene / 4 h / 30 - 45 °C / Industry scale

5.1: hydrazine hydrate; DL-dithiothreitol / dichloromethane / 3 h / 18 - 22 °C / Industry scale

6.1: sodium hydroxide / benzyltri(n-butyl)ammonium chloride / water; tert-butyl methyl ether / 3 h / 17 - 23 °C / Industry scale

7.1: phosphoric acid / isopropyl alcohol / 16 h / 50 °C / Industry scale

7.2: 1.5 h / 0 - 25 °C / Industry scale

8.1: triethylamine / dichloromethane / 20 °C

With DL-dithiothreitol; phosphoric acid; diphenyl phosphoryl azide; hydrazine hydrate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; tetrabutyl-ammonium chloride; benzyltri(n-butyl)ammonium chloride; copper(l) chloride; In dichloromethane; tert-butyl methyl ether; water; isopropyl alcohol; toluene; 1.1: Curtius Rearrangement;