(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid

Base Information

Chemical Name:(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid
CAS No.:87118-44-3
Molecular Formula:C₇H₈O₃S*C₁₂H₁₈N₂O₅S
Molecular Weight:474.556
Hs Code.:

(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid

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Chemical Property of (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid

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Technology Process of (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid

There total 3 articles about (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 87106-45-4
(2S,5R,6R)-6-((Z)-2-Methoxycarbonyl-1-methyl-vinylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester

: 104-15-4
toluene-4-sulfonic acid

: 87118-44-3
(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid

Guidance literature:: In acetone; for 0.166667h; Ambient temperature;
DOI:10.1055/s-1983-30419

Reference yield:

: 551-16-6
6-Aminopenicillanic Acid

: 87118-44-3
(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N(C₂H₅)3 / 1.) CH₂Cl₂, room temp., 2.) 3 h, room temp.

2: 78 percent / dimethylformamide / 3 h

3: 81 percent / acetone / 0.17 h / Ambient temperature

With triethylamine; In N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-1983-30419

Reference yield:

: 87106-41-0
(2S,5R,6R)-6-((Z)-2-Methoxycarbonyl-1-methyl-vinylamino)-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid; compound with triethyl-amine

: 87118-44-3
(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid ethoxycarbonylmethyl ester; compound with toluene-4-sulfonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / dimethylformamide / 3 h

2: 81 percent / acetone / 0.17 h / Ambient temperature

In N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-1983-30419