5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole

Base Information

Chemical Name:5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole
CAS No.:494847-59-5
Molecular Formula:C₄₅H₄₀N₄O₈
Molecular Weight:764.835
Hs Code.:

5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole

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Chemical Property of 5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole

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Technology Process of 5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole

There total 11 articles about 5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 167993-16-0
benzimidazole-5,6-dicarboxylic acid anhydride

: 494847-58-4
2-[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-1,2,3,4,5,6,7,8-octahydro-3-benzazecine

: 494847-59-5
5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole

Guidance literature:: In acetonitrile; for 5h; Heating;
DOI:10.1016/S0223-5234(02)01351-X

Reference yield:

: 5-(2-iodo-phenyl)-pentanal

: 494847-59-5
5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole

Guidance literature:: Multi-step reaction with 11 steps

1: TsCl; Et₃N

2: 69 percent / NaHCO₃; Bu₄NCl / Pd(OAc)2

3: H₂

4: HCl

5: 63 percent / Et₃N / H₂O; dioxane / 48 h / 20 °C

6: 58 percent / diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 23 h / 20 °C

7: 98 percent / trifluoroacetic acid / 1 h / 20 °C

8: 72 percent / acetonitrile / 5 h / Heating

With hydrogenchloride; dmap; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium diacetate; In 1,4-dioxane; dichloromethane; water; acetonitrile; 5: Heck cyclization;
DOI:10.1016/S0223-5234(02)01351-X

Reference yield:

: 3-Hydroxy-2-[5-(2-iodo-phenyl)-pent-(E)-ylideneamino]-propionic acid methyl ester

: 494847-59-5
5-[[[[3,5-bis(benzyloxycarbonyl)phenyl]amino]carbonyl]-[2-(1,2,3,4,5,6,7,8-octahydro-3-benzazecino)carbonyl]]-6-(carboxylic acid)benzimidasole

Guidance literature:: Multi-step reaction with 10 steps

1: TsCl; Et₃N

2: 69 percent / NaHCO₃; Bu₄NCl / Pd(OAc)2

3: H₂

4: HCl

5: 63 percent / Et₃N / H₂O; dioxane / 48 h / 20 °C

6: 58 percent / diisopropylethylamine; bromotris(pyrrolidine)phosphonium hexafluorophosphate; DMAP / CH₂Cl₂ / 23 h / 20 °C

7: 98 percent / trifluoroacetic acid / 1 h / 20 °C

8: 72 percent / acetonitrile / 5 h / Heating

With hydrogenchloride; dmap; tetrabutyl-ammonium chloride; hydrogen; sodium hydrogencarbonate; triethylamine; N-ethyl-N,N-diisopropylamine; p-toluenesulfonyl chloride; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; palladium diacetate; In 1,4-dioxane; dichloromethane; water; acetonitrile; 4: Heck cyclization;
DOI:10.1016/S0223-5234(02)01351-X