O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-β-D-glucopyranosylamine

Base Information

• Chemical Name: O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-β-D-glucopyranosylamine
• CAS No.: 87248-49-5
• Molecular Formula: C₁₀₇H₁₁₀N₂O₂₀
• Molecular Weight: 1744.05
• Mol file: 87248-49-5.mol

Synonyms:

Chemical Property of O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-β-D-glucopyranosylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-β-D-glucopyranosylamine

There total 6 articles about O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-β-D-glucopyranosylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4-tri-O-benzyl-N-(benzyl N-benzyloxycarbonyl-L-β-aspartyl)-α-D-glucopyranosylamine (127570-61-0) + phenylthio-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1→6)-2,3,4-tri-O-benzyl-β-D-glucopyranoside (95084-13-2,95084-12-1) → O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-α-D-glucopyranosylamine (77437-65-1,77481-44-8,87248-49-5,149716-30-3) + C107H110N2O20 (77437-65-1,77481-44-8,87248-49-5,149716-30-3)

Guidance literature:

With N-Bromosuccinimide; trifluorormethanesulfonic acid; In various solvent(s); at -78 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(91)80430-E

Reference yield:

2,3,4-tri-O-benzyl-N-(benzyl N-benzyloxycarbonyl-L-β-aspartyl)-α-D-glucopyranosylamine (127570-61-0) + phenylthio-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1→6)-2,3,4-tri-O-benzyl-β-D-glucopyranoside (95084-13-2,95084-12-1) → O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-α-D-glucopyranosylamine (77437-65-1,77481-44-8,87248-49-5,149716-30-3) + C107H110N2O20 (77437-65-1,77481-44-8,87248-49-5,149716-30-3)

Guidance literature:

With N-Bromosuccinimide; trifluorormethanesulfonic acid; In various solvent(s); at -78 ℃; for 1h; Yield given. Yields of byproduct given;

DOI:10.1016/0040-4039(91)80430-E

Reference yield:

Z-Asp-OBn (4779-31-1) + (3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-[(2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-((2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-tetrahydro-pyran-2-ylamine (77437-63-9,77437-64-0) → O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-α-D-glucopyranosylamine (77437-65-1,77481-44-8,87248-49-5,149716-30-3) + O-(2,3,4,6-Tetra-O-benzyl-α-D-glucopyranosyl)-(1->6)-O-(2,3,4-tri-O-benzyl-β-D-glucopyranosyl)-(1->6)-2,3,4-tri-O-benzyl-N-(benzyl-N-benzyloxycarbonyl-L-asparthyl)-β-D-glucopyranosylamine (77437-65-1,77481-44-8,87248-49-5,149716-30-3)

Guidance literature:

With diethyl cyanophosphonate; In triethylamine; N,N-dimethyl-formamide; Yield given. Yields of byproduct given;

DOI:10.1016/S0008-6215(00)85914-5

upstream raw materials:

Z-Asp-OBn

(3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-[(2R,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-((2S,3R,4S,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yloxymethyl)-tetrahydro-pyran-2-yloxymethyl]-tetrahydro-pyran-2-ylamine

2,3,4-tri-O-benzyl-N-(benzyl N-benzyloxycarbonyl-L-β-aspartyl)-α-D-glucopyranosylamine

phenylthio-(2,3,4,6-tetra-O-benzyl-α-D-glucopyranosyl)-(1→6)-2,3,4-tri-O-benzyl-β-D-glucopyranoside

Downstream raw materials:

O-(α-D-glucopyranosyl)-(1<*>6)-O-β-D-glucopyranosyl-(1<*>6)-N-(L-β-aspartyl)-α-D-glucopyranosylamine