1H-Indole, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-

Base Information

• Chemical Name: 1H-Indole, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-
• CAS No.: 107734-06-5
• Molecular Formula: C21H17NO2S
• Molecular Weight: 347.437
• Mol file: 107734-06-5.mol

Synonyms:

Chemical Property of 1H-Indole, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 1-[(4-methylphenyl)sulfonyl]-2-phenyl-

There total 74 articles about 1H-Indole, 1-[(4-methylphenyl)sulfonyl]-2-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-Ts-2-styrylaniline → N-tosyl-2-phenylindole (107734-06-5)

Guidance literature:

With iron(III) sulfate hydrate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,2-dichloro-ethane; at 120 ℃; for 7h; regioselective reaction; Inert atmosphere;

DOI:10.1039/c6ob00074f

Reference yield: 99.0%

N-tosyl-2-iodoaniline (61613-20-5) + phenylacetylene (536-74-3) → N-tosyl-2-phenylindole (107734-06-5)

Guidance literature:

With copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; for 48h; Inert atmosphere; Reflux;

DOI:10.1002/adsc.201000730

Reference yield: 99.0%

4-methyl-N-{2-(phenylethynyl)phenyl}benzenesulfonamide (442155-91-1) → N-tosyl-2-phenylindole (107734-06-5)

Guidance literature:

With carbon dioxide; potassium carbonate; palladium dichloride; In N,N-dimethyl-formamide; at 65 ℃; for 24h; under 7600.51 Torr;

DOI:10.1021/ol300958c

upstream raw materials:

4-methyl-N-{2-(phenylethynyl)phenyl}benzenesulfonamide

N-tosyl-2-iodoaniline

phenylacetylene

dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate

Downstream raw materials:

2-phenyl-indole

2-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indole

C₃₀H₂₂ClNO₃

C₂₃H₁₉NO₂