Technology Process of C22H21F2N3O4
There total 9 articles about C22H21F2N3O4 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Raney Ni / N,N-dimethyl acetamide / 6 h / 70 °C
2: citric acid; sodium hydroxide / 20 °C
3: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide
With
oxalyl dichloride; citric acid; sodium hydroxide;
In
dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.006
- Guidance literature:
-
Multi-step reaction with 5 steps
1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C
2: Raney Ni / N,N-dimethyl acetamide / 6 h / 70 °C
3: citric acid; sodium hydroxide / 20 °C
4: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide
With
oxalyl dichloride; potassium carbonate; citric acid; sodium hydroxide;
In
dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.006
- Guidance literature:
-
Multi-step reaction with 3 steps
1: citric acid; sodium hydroxide / 20 °C
2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide
With
oxalyl dichloride; citric acid; sodium hydroxide;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.05.006