Technology Process of 1-carbamoyl-3-cyclohexylmethoxy-6-(cyclopropyl)sulfonyl-β-carboline
There total 10 articles about 1-carbamoyl-3-cyclohexylmethoxy-6-(cyclopropyl)sulfonyl-β-carboline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: thionyl chloride / 6.5 h / 0 °C / Inert atmosphere; Reflux
2: potassium permanganate / N,N-dimethyl-formamide / 24.5 h / 20 °C
3: hydrazine hydrate / methanol / 6 h / Reflux
4: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C
5: hydrogenchloride / water / 0.5 h / Reflux
6: hydrogenchloride; sodium nitrite / 2.5 h / 0 - 5 °C
7: 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride / 24 h / Reflux; Inert atmosphere
8: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C
9: chlorosulfonic acid / 0 - 5 °C
10: water / 20 °C
With
1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; chlorosulfonic acid; potassium permanganate; thionyl chloride; sulfuric acid; dihydrogen peroxide; sodium hydride; hydrazine hydrate; iron(II) sulfate; sodium nitrite;
In
methanol; water; N,N-dimethyl-formamide;
5: Curtius rearrangement / 8: Minisci reaction;
DOI:10.1080/00397911.2010.546552
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C
2: chlorosulfonic acid / 0 - 5 °C
3: water / 20 °C
With
chlorosulfonic acid; sulfuric acid; dihydrogen peroxide; iron(II) sulfate;
In
water;
1: Minisci reaction;
DOI:10.1080/00397911.2010.546552
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogenchloride; sodium nitrite / 2.5 h / 0 - 5 °C
2: 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride / 24 h / Reflux; Inert atmosphere
3: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C
4: chlorosulfonic acid / 0 - 5 °C
5: water / 20 °C
With
1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; chlorosulfonic acid; sulfuric acid; dihydrogen peroxide; sodium hydride; iron(II) sulfate; sodium nitrite;
In
water;
3: Minisci reaction;
DOI:10.1080/00397911.2010.546552
