tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate

Base Information

• Chemical Name: tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate
• CAS No.: 362697-53-8
• Molecular Formula: C₃₀H₃₆N₄O₆
• Molecular Weight: 548.639
• Mol file: 362697-53-8.mol

Synonyms:

Chemical Property of tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate

There total 5 articles about tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

→ tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate (362697-53-8)

Guidance literature:

Reference yield:

4-methoxycarbonylmethyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester (362703-58-0) → tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate (362697-53-8)

Guidance literature:

With potassium hydroxide; hydroxylamine; In methanol;

DOI:10.1016/j.bmcl.2006.02.015

Reference yield:

tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (362703-57-9) → tert-butyl 4-[2-(hydroxyamino)-2-oxoethyl]-4-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-piperidinecarboxylate (362697-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: BOP; N-methylmorpholine / dimethylformamide

2: NH₂OH; KOH / methanol

With 4-methyl-morpholine; potassium hydroxide; hydroxylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2006.02.015

upstream raw materials:

4-methoxycarbonylmethyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate

N-tert-butyloxycarbonylpiperidin-4-one

1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylene]piperidine