METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE

Base Information

• Chemical Name: METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE
• CAS No.: 362703-57-9
• Molecular Formula: C₁₃H₂₄N₂O₄
• Molecular Weight: 272.345
• Hs Code.: 2933399090
• Mol file: 362703-57-9.mol

Synonyms:tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate;4-Piperidineacetic acid, 4-amino-1-[(1,1-dimethylethoxy)carbonyl]-, methyl ester;4-Amino-1-[(tert-butoxy)carbonyl]-4-piperidineacetic acid methyl ester

Chemical Property of METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE

Chemical Property:

• Vapor Pressure: 5.04E-05mmHg at 25°C
• Refractive Index: 1.48
• Boiling Point: 348.4°Cat760mmHg
• Flash Point: 164.5°C
• PSA: 81.86000
• Density: 1.096g/cm³
• LogP: 1.91610
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl Dl-2-(1-Boc-Piperidin-4-Yl)-β-Glycinate can be used as SHP2 protein tyrosine phosphatase inhibitors.

Technology Process of METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE

There total 4 articles about METHYL DL-2-(1-BOC-PIPERIDIN-4-YL)-BETA-GLYCINATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylene]piperidine (169206-65-9) → tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (362703-57-9)

Guidance literature:

With ammonia; In ethanol; at 12 ℃; for 80h; A stainless steel bomb reactor;

Reference yield: 67.0%

4-amino-4-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester (1159983-30-8) + diazomethyl-trimethyl-silane (18107-18-1) → tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (362703-57-9)

Guidance literature:

In methanol; hexane; benzene; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.1c10150

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-amino-4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (362703-57-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: NH₃ / methanol / 80 °C

With ammonia; In methanol; toluene; 1: Wittig olefination;

DOI:10.1016/j.bmcl.2006.02.015

upstream raw materials:

1-tert-butoxycarbonyl-4-[(methoxycarbonyl)methylene]piperidine

N-tert-butyloxycarbonylpiperidin-4-one

4-amino-4-carboxymethylpiperidine-1-carboxylic acid tert-butyl ester

diazomethyl-trimethyl-silane

Downstream raw materials:

4-methoxycarbonylmethyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester

{1-methyl-4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-piperidin-4-yl}-acetic acid methyl ester

{4-[4-(2-methyl-quinolin-4-ylmethoxy)-benzoylamino]-piperidin-4-yl}-acetic acid methyl ester

N-{4-[2-(hydroxyamino)-2-oxoethyl]-4-piperidinyl}-4-[(2-methyl-4-quinolinyl)methoxy]benzamide