(2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide

Base Information

Chemical Name:(2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide
CAS No.:1562381-72-9
Molecular Formula:C₂₄H₂₂N₂O₃S
Molecular Weight:418.516
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide

Chemical Property:

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Technology Process of (2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide

There total 18 articles about (2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562381-58-1
4-hydroxy-N-methyl-N',4-diphenyl-N-tosylbut-2-ynimidamide

: C₂₄H₂₂N₂O₃S

: 1562381-72-9
(2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In dimethyl sulfoxide; at 110 ℃; for 18h; Overall yield = 81 %; Inert atmosphere;
DOI:10.1021/ja412634w

Reference yield:

: 640-61-9
N-methyl-p-toluenesulfonylamide

: C₂₄H₂₂N₂O₃S

: 1562381-72-9
(2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / toluene / 80 °C / Inert atmosphere; Sealed tube

2.1: zinc trifluoromethanesulfonate / dichloromethane / 2.5 h / 50 °C / Inert atmosphere

3.1: diisopropylamine; zinc dibromide; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Sealed tube

3.2: 0.5 h / 28 °C / Inert atmosphere; Sealed tube

4.1: 1,4-diaza-bicyclo[2.2.2]octane / dimethyl sulfoxide / 18 h / 110 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl trifluoromethanesulfonate; zinc trifluoromethanesulfonate; potassium carbonate; diisopropylamine; zinc dibromide; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ja412634w

Reference yield:

: 1608-03-3,5622-76-4,146276-26-8,935-01-3
(E)-but-1-en-3-yn-1-ylbenzene

: C₂₄H₂₂N₂O₃S

: 1562381-72-9
(2E)-N-methyl-4-oxo-N',4-diphenyl-N-tosylbut-2-enimidamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide; silver nitrate / acetone / 1 h / 20 °C / Inert atmosphere

2.1: 1,10-Phenanthroline; potassium carbonate; copper(ll) sulfate pentahydrate / toluene / 80 °C / Inert atmosphere; Sealed tube

3.1: zinc trifluoromethanesulfonate / 1,2-dichloro-ethane / 2 h / 60 °C / Inert atmosphere

4.1: diisopropylamine; zinc dibromide; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 3 h / 20 °C / Inert atmosphere; Sealed tube

4.2: 0.5 h / 28 °C / Inert atmosphere; Sealed tube

5.1: 1,4-diaza-bicyclo[2.2.2]octane / dimethyl sulfoxide / 18 h / 110 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; trimethylsilyl trifluoromethanesulfonate; zinc trifluoromethanesulfonate; potassium carbonate; silver nitrate; diisopropylamine; zinc dibromide; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; acetone; toluene;
DOI:10.1021/ja412634w