3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

Base Information

Chemical Name:3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester
CAS No.:129112-72-7
Molecular Formula:C₃₇H₄₅N₃O₆
Molecular Weight:627.781
Hs Code.:

3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

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Chemical Property of 3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

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Technology Process of 3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

There total 7 articles about 3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 129112-71-6,129212-64-2
3-Benzyloxycarbonyl-5-(3-benzyloxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

: 129112-72-7,129172-76-5
3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

Guidance literature:: With hydrogen; palladium on activated charcoal; In dichloromethane; isopropyl alcohol; at 45 ℃; for 15h;
DOI:10.1016/S0040-4020(01)86687-4

Reference yield: 85.0%

: 129112-77-2,129260-99-7
12-(4-Dimethylamino-2-methoxy-phenyl)-9-(3-hydroxy-propyl)-6,7,8,9,10,11,12,13-octahydro-5H-7,13-diaza-cyclodeca[a]indene-12-carboxylic acid methyl ester

: 501-53-1,94274-21-2
benzyl chloroformate

: 129112-72-7,129172-76-5
3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

Guidance literature:: With potassium carbonate; In dichloromethane; for 0.25h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86687-4

Reference yield:

: 15799-79-8
3-methoxy-N,N-dimethylaniline

: 129112-72-7,129172-76-5
3-Benzyloxycarbonyl-5-(3-hydroxypropyl)-8-<2-methoxy-4-(N,N-dimethylamino)-phenyl>-1,2,4,5,6,7,8,9-octahydro-3H-azecino<5,4-b>-indol-8-carbonsaeuremethylester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) tert.-butylhypochlorite; 2.) boron trifluoride-etherate / 1.) triethylamine / 0 deg C; 1.) dichloromethane, tetrachloromethane; 2.) 1h

2: 80 percent / hydrogen / Pd/C / propan-2-ol / 40 °C

3: 2.) 15percent potassium carbonate / 1.) acetyl chloride, 114h, reflux; 2.) dichloromethane, 10 min

With tert-butylhypochlorite; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; palladium on activated charcoal; triethylamine; In isopropyl alcohol;
DOI:10.1016/S0040-4020(01)86687-4