N-(2-bromophenyl)-3-methylbutanamide

Base Information

• Chemical Name: N-(2-bromophenyl)-3-methylbutanamide
• CAS No.: 349540-68-7
• Molecular Formula: C₁₁H₁₄BrNO
• Molecular Weight: 256.142
• Mol file: 349540-68-7.mol

Synonyms:

Chemical Property of N-(2-bromophenyl)-3-methylbutanamide

Chemical Property:

Purity/Quality:

N-(2-BROMOPHENYL)-3-METHYLBUTANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromophenyl)-3-methylbutanamide

There total 1 articles about N-(2-bromophenyl)-3-methylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

isopentanoyl chloride (108-12-3) + 2-bromoaniline (615-36-1) → N-isovaleryl-2-bromoaniline (349540-68-7)

Guidance literature:

With sodium hydroxide; In tert-butyl methyl ether; at 10 - 30 ℃; for 1.5h; Industrial scale;

Reference yield:

N-isovaleryl-2-bromoaniline (349540-68-7) → C47H43BNOPPd

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: chlorocarbonylbis(triphenylphosphine)iridium(I) / toluene / 0.5 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C / Inert atmosphere

4.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

4.2: 4 h / -78 - 20 °C / Inert atmosphere

5.1: dichloromethane / 4 h / 20 °C

With n-butyllithium; chlorocarbonylbis(triphenylphosphine)iridium(I); sodium hydride; In tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil;

DOI:10.1021/jacs.6b09759

Reference yield:

N-isovaleryl-2-bromoaniline (349540-68-7) → C12H16BrN

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: chlorocarbonylbis(triphenylphosphine)iridium(I) / toluene / 0.5 h / 20 °C

With chlorocarbonylbis(triphenylphosphine)iridium(I); sodium hydride; In tetrahydrofuran; toluene; mineral oil;

DOI:10.1021/jacs.6b09759

upstream raw materials:

isopentanoyl chloride

2-bromoaniline