N-Benzyl-N-(5-ethylthiophen-2-yl)acetamide

Base Information

Chemical Name:N-Benzyl-N-(5-ethylthiophen-2-yl)acetamide
CAS No.:108228-53-1
Molecular Formula:C₁₅H₁₇NOS
Molecular Weight:259.372
Hs Code.:
DSSTox Substance ID:DTXSID90547297
Mol file:108228-53-1.mol

Synonyms:108228-53-1;N-Benzyl-N-(5-ethylthiophen-2-yl)acetamide;DTXSID90547297

Suppliers and Price of N-Benzyl-N-(5-ethylthiophen-2-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Benzyl-N-(5-ethylthiophen-2-yl)acetamide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:259.10308534
Heavy Atom Count:18
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CC=C(S1)N(CC2=CC=CC=C2)C(=O)C

Technology Process of N-Benzyl-N-(5-ethylthiophen-2-yl)acetamide

There total 4 articles about N-Benzyl-N-(5-ethylthiophen-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzyl-[5-(1-iodo-ethyl)-dihydro-thiophen-(2E)-ylidene]-amine; hydriodide

: 108228-53-1
2-(N-acetyl-N-benzylamino)-5-ethylthiophene

Guidance literature:: Multi-step reaction with 2 steps

1: DBU / tetrahydrofuran

2: DBU / DMAP / CH₂Cl₂

With 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c39860001671

Reference yield:

: 75-36-5
acetyl chloride

: Benzyl-[5-eth-(Z)-ylidene-dihydro-thiophen-(2E)-ylidene]-amine

: 108228-53-1
2-(N-acetyl-N-benzylamino)-5-ethylthiophene

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; dmap; In dichloromethane; Yield given;
DOI:10.1039/c39860001671

Reference yield:

: 14309-88-7
N-benzylthioacetamide

: 108228-53-1
2-(N-acetyl-N-benzylamino)-5-ethylthiophene

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 1 h, 2.) THF, -78 deg C to RT

2: 1.) iodine, 2.) DBU / 1.) THF, RT, 15 h, 2.) THF, RT, 2 h

3: DBU, DMAP / CH₂Cl₂ / Ambient temperature

With dmap; n-butyllithium; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane;
DOI:10.1016/S0040-4020(01)86180-9