2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene

Base Information

• Chemical Name: 2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene
• CAS No.: 140655-35-2
• Molecular Formula: C₁₈H₁₉NO
• Molecular Weight: 265.355

Synonyms:

Chemical Property of 2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene

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Technology Process of 2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene

There total 5 articles about 2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5H-5-methyl-2-phenyl-5-(2-propynyl)oxy-6,7,8,9-tetrahydrocycloheptapyrimidine (140655-22-7) → 2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene (140655-35-2)

Guidance literature:

In nitrobenzene; at 140 ℃;

DOI:10.1016/S0040-4020(01)88723-8

Reference yield:

cycloheptane-1,3-dione (1194-18-9) → 2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene (140655-35-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent

2: 79 percent / tetrahydrofuran / 2 h / Heating

3: 1) NaH / 1) THF, r.t., 2) reflux, 24 h

4: 92 percent / nitrobenzene / 140 °C / t1/2

With sodium hydride; In tetrahydrofuran; nitrobenzene;

DOI:10.1016/S0040-4020(01)88723-8

Reference yield:

5H-2-phenyl-6,7,8,9-tetrahydrocycloheptapyrimidin-5-one (140655-01-2) → 2H-1,6,7,8,9,9a-hexahydro-9a-methyl-4-phenyl-1-oxa-5-azabenzazulene (140655-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / tetrahydrofuran / 2 h / Heating

2: 1) NaH / 1) THF, r.t., 2) reflux, 24 h

3: 92 percent / nitrobenzene / 140 °C / t1/2

With sodium hydride; In tetrahydrofuran; nitrobenzene;

DOI:10.1016/S0040-4020(01)88723-8

upstream raw materials:

5H-5-methyl-2-phenyl-5-(2-propynyl)oxy-6,7,8,9-tetrahydrocycloheptapyrimidine

cycloheptane-1,3-dione

5H-2-phenyl-6,7,8,9-tetrahydrocycloheptapyrimidin-5-one

5H-5-hydroxy-5-methyl-2-phenyl-6,7,8,9-tetrahydrocycloheptapyrimidine

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