(+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine

Base Information

Chemical Name:(+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine
CAS No.:78341-35-2
Molecular Formula:C₂₂H₂₅NO₄
Molecular Weight:367.445
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine

There total 12 articles about (+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78278-48-5
6-(3-benzyloxy-4-methoxy)-7-(4-benzyloxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine

: 78341-35-2
(+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine

Guidance literature:: With hydrogenchloride; In methanol; for 2h; Yield given; Heating; also with ⁽¹⁴⁾C labelling;
DOI:10.1016/S0040-4020(01)92028-9

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 78341-35-2
(+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / benzene / 2 h / Heating; ⁽¹⁴⁾C labelling

2: pyridine / benzene / 20 h / Ambient temperature; ⁽¹⁴⁾C labelling

3: 230 mg / 5percent KOH / ethanol / 3 h / Heating; ⁽¹⁴⁾C labelling

4: 162 mg / LAH, AlCl₃ / tetrahydrofuran; diethyl ether / 1.) ice cooling, 2.) 14 h, room temperature ; also with ⁽¹⁴⁾C labelling

5: 11 N HCl / methanol / 2 h / Heating; also with ⁽¹⁴⁾C labelling

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; benzene;
DOI:10.1016/S0040-4020(01)92028-9

Reference yield:

: 1699-38-3
3-benzyloxy-4-methoxy-benzyl chloride

: 78341-35-2
(+/-)-6-(3-hydroxy-4-methoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine

Guidance literature:: Multi-step reaction with 7 steps

1: dimethylsulfoxide / 24 h / also with ⁽¹⁴⁾C labelling

2: 200 mg / KOH / ethane-1,2-diol; H₂O / 20 h / Heating; also with ⁽¹⁴⁾C labelling

3: SOCl₂ / benzene / 2 h / Heating; ⁽¹⁴⁾C labelling

4: pyridine / benzene / 20 h / Ambient temperature; ⁽¹⁴⁾C labelling

5: 230 mg / 5percent KOH / ethanol / 3 h / Heating; ⁽¹⁴⁾C labelling

6: 162 mg / LAH, AlCl₃ / tetrahydrofuran; diethyl ether / 1.) ice cooling, 2.) 14 h, room temperature ; also with ⁽¹⁴⁾C labelling

7: 11 N HCl / methanol / 2 h / Heating; also with ⁽¹⁴⁾C labelling

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; water; ethylene glycol; dimethyl sulfoxide; benzene;
DOI:10.1016/S0040-4020(01)92028-9