3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride

Base Information

Chemical Name:3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride
CAS No.:1261352-22-0
Molecular Formula:C₁₄H₁₆N₄O₄*ClH
Molecular Weight:340.766
Hs Code.:

Synonyms:

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Chemical Property of 3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride

Chemical Property:

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Technology Process of 3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride

There total 8 articles about 3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1261352-30-0
C₁₉H₂₄N₄O₆

: 1261352-22-0
3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; water; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2010.09.139

Reference yield:

: 1261352-28-6
methyl N-(tert-butoxycarbonyl)-3-{1-[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]-1H-1,2,3-triazol-5-yl}-L-alaninate

: 1261352-22-0
3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane; water / 0 - 20 °C

With hydrogenchloride; water; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1016/j.bmcl.2010.09.139

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1261352-22-0
3-{1-[(1S)-1-carboxy-2-phenylethyl]-1H-1,2,3-triazol-5-yl}-L-alanine hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: copper(ll) sulfate pentahydrate; triflic azide; triethylamine / water; acetonitrile / 0.5 h / 0 °C

2: thionyl chloride / 0 - 20 °C / Inert atmosphere

3: pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride / tetrahydrofuran / 3 h / Reflux; Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

5: hydrogenchloride / 1,4-dioxane; water / 0 - 20 °C

With hydrogenchloride; thionyl chloride; copper(ll) sulfate pentahydrate; pentamethylcyclopentadienyl bis(triphenylphosphine)ruthenium(II) chloride; triflic azide; water; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; 3: Huisgen Cycloaddition;
DOI:10.1016/j.bmcl.2010.09.139