Benzenepropanamide, N,N,a-trimethyl-b-oxo-

Base Information

• Chemical Name: Benzenepropanamide, N,N,a-trimethyl-b-oxo-
• CAS No.: 108471-82-5
• Molecular Formula: C12H15NO2
• Molecular Weight: 205.257
• Mol file: 108471-82-5.mol

Synonyms:

Chemical Property of Benzenepropanamide, N,N,a-trimethyl-b-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanamide, N,N,a-trimethyl-b-oxo-

There total 8 articles about Benzenepropanamide, N,N,a-trimethyl-b-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + N,N-dimethyl-propanamide (758-96-3) → N,N,2-trimethyl-3-oxo-3-phenylpropanamide (108471-82-5)

Guidance literature:

N,N-dimethyl-propanamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h; Inert atmosphere;

benzoic acid methyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.202006383

Reference yield: 68.0%

N,N-Dimethylacrylamide (2680-03-7,68761-83-1) + benzaldehyde (100-52-7) → N,N,2-trimethyl-3-oxo-3-phenylpropanamide (108471-82-5)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel⁽⁰⁾; tricyclohexylphosphine; In toluene; at 120 ℃; for 36h; regioselective reaction; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.6b00024

Reference yield: 62.0%

2-Dimethylamino-5-methyl-4-phenyl-[1,3]oxazin-6-one (106013-79-0) → N,N,2-trimethyl-3-oxo-3-phenylpropanamide (108471-82-5)

Guidance literature:

With water; In 1,4-dioxane; at 110 ℃; for 16h;

DOI:10.1021/jo00391a048

upstream raw materials:

3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide

2-Dimethylamino-5-methyl-4-phenyl-[1,3]oxazin-6-one

((Z)-2-Dimethylcarbamoyl-1-phenyl-propenyl)-carbamic acid methyl ester

N,N-dimethyl-propanamide

Downstream raw materials:

(1RS,2SR)-3-(dimethylamino)-2-methyl-1-phenyl-1-propanol

3-hydroxy-3-phenyl-2,N,N-trimethylpropionamide