1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide

Base Information

• Chemical Name: 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide
• CAS No.: 1400742-16-6
• Molecular Formula: C₂₂H₂₆FN₃O
• Molecular Weight: 367.466

Synonyms:

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Chemical Property of 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide

Chemical Property:

• Boiling Point: 574.7±40.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: 5-fluoro AB-PINACA is a derivative of the synthetic cannabinoid AB-PINACA , which has recently been identified in illegal herbal products. 5-fluoro CUMYL-PINACA is an analog of 5-fluoro AB-PINACA in which the 1-amino-3-methyl-1-oxobutanyl group has been replaced with a cumyl group. The physiological and toxicological properties of 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide are not known. 5-fluoro CUMYL-PINACA is regulated as a Schedule I compound in the United States. This product is intended for research and forensic applications.

Technology Process of 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide

There total 3 articles about 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-Fluoropentyl)-1H-indazole-3-carboxylic Acid + 2-phenyl-2-propylamine (585-32-0) → 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide (1400742-16-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 14h; Inert atmosphere;

DOI:10.1021/acschemneuro.7b00267

Reference yield:

3-methoxycarbonylindole (942-24-5) → 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide (1400742-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 48 h / 0 °C

2.1: sodium hydroxide; water / methanol / 18 h / Reflux; Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 14 h / 20 °C / Inert atmosphere

With potassium tert-butylate; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide;

DOI:10.1021/acschemneuro.7b00267

Reference yield:

Methyl 1-(5-Fluoropentyl)-1H-indazole-3-carboxylate → 1-(5-fluoropentyl)-N-(1-methyl-1-phenylethyl)-1H-indazole-3-carboxamide (1400742-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / methanol / 18 h / Reflux; Inert atmosphere

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 14 h / 20 °C / Inert atmosphere

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dimethyl sulfoxide;

DOI:10.1021/acschemneuro.7b00267

upstream raw materials:

2-phenyl-2-propylamine

3-methoxycarbonylindole