1449401-87-9

Base Information

• Chemical Name: 1449401-87-9
• CAS No.: 1449401-87-9
• Molecular Formula: C₁₇H₁₁BrN₂
• Molecular Weight: 323.192
• Mol file: 1449401-87-9.mol

Synonyms:

Chemical Property of 1449401-87-9

Chemical Property:

• Boiling Point: 472.6±38.0 °C(Predicted)
• PKA: 5.76±0.30(Predicted)
• Density: 1.46±0.1 g/cm3(Predicted)

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1449401-87-9

There total 5 articles about 1449401-87-9 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

5-phenyl-5H-pyrido[3,2-b]indole → 8-bromo-5-phenyl-5H-pyridine[3,2-b]indole (1449401-87-9)

Guidance literature:

With N-Bromosuccinimide; acetic acid; at 20 ℃; for 2h;

Reference yield:

phenylboronic acid (98-80-6) → 8-bromo-5-phenyl-5H-pyridine[3,2-b]indole (1449401-87-9)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / Inert atmosphere; Reflux

2: triphenylphosphine / 1,2-dichloro-benzene / 20 h / Reflux

3: potassium phosphate; copper(l) iodide; rac-diaminocyclohexane / toluene / 16 h / Inert atmosphere; Reflux

4: acetic acid; N-Bromosuccinimide / 2 h / 20 °C

With potassium phosphate; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; acetic acid; rac-diaminocyclohexane; triphenylphosphine; In 1,2-dimethoxyethane; water; 1,2-dichloro-benzene; toluene;

Reference yield:

2-phenyl-3-nitropyridine (134896-35-8) → 8-bromo-5-phenyl-5H-pyridine[3,2-b]indole (1449401-87-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine / 1,2-dichloro-benzene / 20 h / Reflux

2: potassium phosphate; copper(l) iodide; rac-diaminocyclohexane / toluene / 16 h / Inert atmosphere; Reflux

3: acetic acid; N-Bromosuccinimide / 2 h / 20 °C

With potassium phosphate; N-Bromosuccinimide; copper(l) iodide; acetic acid; rac-diaminocyclohexane; triphenylphosphine; In 1,2-dichloro-benzene; toluene;

upstream raw materials:

phenylboronic acid

2-phenyl-3-nitropyridine

5H-pyrido[3,2-b]indole

Refernces

• 1、 -. "ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES". Paragraph 0134. . Retrieved 2019/03/15.