134896-35-8

Basic information

• Product Name: 2-PHENYL-3-NITROPYRIDINE
• Synonyms: 2-PHENYL-3-NITROPYRIDINE;3-NITRO-2-PHENYLPYRIDINE
• CAS NO: 134896-35-8
• Molecular Formula: C₁₁H₈N₂O₂
• Molecular Weight: 200.19
• Mol File: 134896-35-8.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 328.5 °C at 760 mmHg
• Flash Point: 152.4 °C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 0.000362mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-PHENYL-3-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PHENYL-3-NITROPYRIDINE(134896-35-8)
• EPA Substance Registry System: 2-PHENYL-3-NITROPYRIDINE(134896-35-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 134896-35-8(Hazardous Substances Data)

Usage

General Description

2-Phenyl-3-nitropyridine, often noted by its molecular formula C11H8N2O2, is an organic compound that belongs to the class of organic compounds known as phenylpyridines, which are polycyclic aromatic compounds containing a benzene ring linked to a pyridine ring through a CC or CN bond. The molecular structure consists of phenyl and pyridine groups, with a nitro group attached to the pyridine ring. 2-PHENYL-3-NITROPYRIDINE is noted for its light yellow crystalline appearance and is predominantly used in the field of organic synthesis. It exhibits properties typical for nitroaromatic compounds, which are often used as precursors in the synthesis of a wide range of industrial and specialty chemicals.

InChI:InChI=1/C11H8N2O2/c14-13(15)10-7-4-8-12-11(10)9-5-2-1-3-6-9/h1-8H

Upstream product

• 19755-53-4 2-bromo-3-nitropyridine 
• 98-80-6 phenylboronic acid 
• 5470-18-8 2-Chloro-3-nitropyridine 

Downstream Products

• 136871-75-5 (2S,3S)-2-phenyl-3-piperidinamine 
• 160551-72-4 cis-(+/-)-2-phenylpiperidin-3-ylamine 
• 161167-79-9 cis-3-amino-2-phenyl-piperidine 
• 1449401-87-9 8-bromo-5-phenyl-5H-pyridine[3,2-b]indole 
• 1049706-69-5 2-phenyl-3-nitro-6-chloropyridine 
• 101601-80-3 3-amino-2-phenylpyridine 
• 1346545-68-3 5-benzyl-5H-pyrido[3,2-b]indole 

Relevant articles and documents

3,3'-((Arylmethylene)bis(4-methoxy-3,1-phenylene)) dipyridine derivatives as convenient ligands for Suzuki–Miyaura chemo- and homoselective cross-coupling reactions

Four novel N,N-bidentate triarylmethane-based ligands bearing β-pyridyl residues have been prepared and the catalytic activity of their in-situ generated palladium complexes were studied in the Suzuki–Miyaura cross-coupling reactions. Air and moisture stable 3,3'-((arylmethylene)bis(4-methoxy-3,1-phenylene))dipyridines L1-3 showed excellent activity in the Suzuki coupling reactions of aryl halides with aryl boronic acids under thermal and sonochemical reaction conditions. The described methodology provided good to high yields in short reaction times at ambient conditions. Moreover, it offered a straightforward way for Suzuki–Miyaura chemo- and homoselective cross-coupling of aryl halides with phenyl boronic acid. The structures of synthesized compounds were fully characterized by FT-IR, 1H-NMR, 13C-NMR, and elemental analyses. The coordination of palladium acetate to nitrogen sites of L1 was also studied using FTIR spectroscopy, EDX analysis and SEM observations. Graphic abstract: The in-situ generated Pd-complexes of N,N-bidentate ligands L1-3 are described as robust and highly effective catalytic systems for the Suzuki cross-coupling of aryl halides with aryl boronic acids under thermal and sonochemical reaction conditions.[Figure not available: see fulltext.]

C6-Selective Direct Arylation of 2-Phenylpyridine via an Activated N-methylpyridinium Salt: A Combined Experimental and Theoretical Study

An elegant pre-activation strategy, based on the formation of N-methylpyridinium iodide salts for C6-selective direct arylation of 2-phenylpyridines using Pd/Cu cooperative catalysis, has been developed. By this methodology, a wide range of unsymmetrical 2, 6-diarylpyridines were synthesized with high reactivity and regioselectivity as well as good functional group tolerance. In particular, challenging substrates bearing electron donating groups (EDGs), such as OMe, NMe2, were also successfully employed in this reaction. Deuterium incorporation studies revealed that the C?H bond acidity is improved significantly in N-methylpyridinium salts compared with their N-Oxide and N-iminopyridinium ylide counterparts, thus solving the long-standing problem associated with previous strategies for the synthesis of diaryl pyridines. Finally, the control experiments and DFT calculations supported a Pd-catalyzed and Cu-mediated mechanism in which a carbenoid copper species that is formed in-situ from N-methylpyridinium salts, participates in a Pd-catalyzed arylation followed by an iodide-promoted N-demethylation process. (Figure presented.).

Disubstituted derivative of carboline, and preparation method and application thereof

The invention especially relates to a disubstituted derivative of carboline, and a preparation method and application thereof, belonging to the technical field of organic electroluminescent materials. The disubstituted derivative of carboline can be used