[3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt

Base Information

Chemical Name:[3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt
CAS No.:1369390-22-6
Molecular Formula:C₂F₃O₂*C₃₄H₄₆Cl₂N₅O₅S
Molecular Weight:820.758
Hs Code.:

[3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt

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Chemical Property of [3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt

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Technology Process of [3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt

There total 4 articles about [3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₃Cl₂N₅O₅S

: 76-05-1
trifluoroacetic acid

: 74-88-4
methyl iodide

: 1369390-22-6
[3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt

Guidance literature:: C₃₃H₄₃Cl₂N₅O₅S; methyl iodide;

trifluoroacetic acid; In acetonitrile;
DOI:10.1016/j.bmc.2012.01.036

Reference yield:

: C₉H₁₉N₃O*2ClH

: 1369390-22-6
[3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / Reflux

1.2: 0.5 h / 20 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.036

Reference yield:

: 77279-01-7
C₁₄H₂₇N₃O₃

: 1369390-22-6
[3-(4-(4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydro-pyran-4-carbonyl)-piperazin-1-yl)-propyl]-trimethyl-ammonium trifluoroacetate salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol; dichloromethane / 4 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / Reflux

2.2: 0.5 h / 20 °C

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.01.036