1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin
• CAS No.: 96168-79-5
• Molecular Formula: C₂₁H₂₆O₃
• Molecular Weight: 326.436
• Mol file: 96168-79-5.mol

Synonyms:

Chemical Property of 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin

There total 5 articles about 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-dimethoxylnaphthalene (5486-55-5,117119-43-4) → 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin (96168-79-5)

Guidance literature:

Multi-step reaction with 4 steps

1: Na, 3-methyl-butan-1-ol

2: aq. HCO₂H

3: dioxane; diethyl ether / (methylation)

4: (i) Li, nBuBr, Et₂O, (ii) /BRN= 2581191/

With formic acid; i-Amyl alcohol; sodium; In 1,4-dioxane; diethyl ether;

DOI:10.1021/jm00334a026

Reference yield:

3,7-dimethoxy-1,2-dihydro-naphthalene (65472-33-5) → 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin (96168-79-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. HCO₂H

2: dioxane; diethyl ether / (methylation)

3: (i) Li, nBuBr, Et₂O, (ii) /BRN= 2581191/

With formic acid; In 1,4-dioxane; diethyl ether;

DOI:10.1021/jm00334a026

Reference yield:

sodium 2-naphthol-6-sulfonate (135-76-2) → 1,2,3,4-Tetrahydro-2-hydroxy-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin (96168-79-5)

Guidance literature:

Multi-step reaction with 6 steps

1: KOH, NaOH / 325 °C

2: (i) Na, MeOH, (ii) /BRN= 609209/, dioxane

3: Na, 3-methyl-butan-1-ol

4: aq. HCO₂H

5: dioxane; diethyl ether / (methylation)

6: (i) Li, nBuBr, Et₂O, (ii) /BRN= 2581191/

With potassium hydroxide; sodium hydroxide; formic acid; i-Amyl alcohol; sodium; In 1,4-dioxane; diethyl ether;

DOI:10.1021/jm00334a026

upstream raw materials:

2-methyl-4-bromoanisole

6-methoxy-1,1-dimethyl-3,4-dihydronaphthalene-2(1H)-one

2,6-dimethoxylnaphthalene

3,7-dimethoxy-1,2-dihydro-naphthalene

Downstream raw materials:

1,4-Dihydro-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin

1,2,3,4,5,8-Hexahydro-6-methoxy-2-(4-methoxy-m-tolyl)-1,1-dimethyl-naphthalin