(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:108998-82-9
Molecular Formula:C₃₈H₅₁NO₇Si
Molecular Weight:661.911
Hs Code.:

(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:

Suppliers and Price of (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 34 articles about (2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 108998-79-4,108998-82-9
(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(R)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 84.8 percent / triethylamine / CH₂Cl₂ / 6 h / 0 °C

2: 98.9 percent / imidazole / dimethylformamide / 24 h

3: 82.5 percent / sodium bicarbonate, m-chloroperbenzoic acid / CH₂Cl₂ / 48 h / Ambient temperature

4: 47 percent / boron trifluoride etherate / CH₂Cl₂ / 0.03 h / -78 °C / magnesium triflate

5: 1.) dimethylsulfoxide, trifluoroacetic anhydride 2.) triethylamine / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) 0 deg C, 45 min

With 1H-imidazole; boron trifluoride diethyl etherate; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(86)80005-9

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 108998-79-4,108998-82-9
(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(S)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 84.8 percent / triethylamine / CH₂Cl₂ / 6 h / 0 °C

2: 98.9 percent / imidazole / dimethylformamide / 24 h

3: 82.5 percent / sodium bicarbonate, m-chloroperbenzoic acid / CH₂Cl₂ / 48 h / Ambient temperature

4: 47 percent / boron trifluoride etherate / CH₂Cl₂ / 0.03 h / -78 °C / magnesium triflate

5: 1.) dimethylsulfoxide, trifluoroacetic anhydride 2.) triethylamine / 1.) CH₂Cl₂, -78 deg C, 1 h, 2.) 0 deg C, 45 min

6: 30.2 percent

With 1H-imidazole; boron trifluoride diethyl etherate; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4020(86)80005-9

Reference yield:

: 21210-43-5
(S)-Methyl mandelate

: 108998-79-4,108998-82-9
(2R,3R)-3-(tert-Butyl-dimethyl-silanyloxy)-2-[(S)-1-hydroxy-2-((S)-2-hydroxy-1,2,2-triphenyl-ethoxycarbonyl)-ethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / diethyl ether / 2 h / Heating

2: 62 percent / pyridine / 12 h / Ambient temperature

3: 30.2 percent

With pyridine; In diethyl ether;
DOI:10.1016/0040-4020(86)80005-9