4-(4-METHOXYPHENYL)-5-PYRIDIN-4-YL-4H-1,2,4-TRIAZOLE-3-THIOL

Base Information

• Chemical Name: 4-(4-METHOXYPHENYL)-5-PYRIDIN-4-YL-4H-1,2,4-TRIAZOLE-3-THIOL
• CAS No.: 109220-26-0
• Molecular Formula: C14H12N4OS
• Molecular Weight: 284.341
• Mol file: 109220-26-0.mol

Synonyms:4-(4-methoxyphenyl)-5-(pyridin-4-yl)-2H-1,2,4-triazole-3(4H)-thione;4-(4-methoxy-phenyl)-5-[4]pyridyl-2,4-dihydro-[1,2,4]triazole-3-thione;4-(4-Methoxy-phenyl)-5-[4]pyridyl-2,4-dihydro-[1,2,4]triazol-3-thion;

Chemical Property of 4-(4-METHOXYPHENYL)-5-PYRIDIN-4-YL-4H-1,2,4-TRIAZOLE-3-THIOL

Chemical Property:

• PSA: 87.82000
• LogP: 3.00050

Purity/Quality:

4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(4-METHOXYPHENYL)-5-PYRIDIN-4-YL-4H-1,2,4-TRIAZOLE-3-THIOL

There total 11 articles about 4-(4-METHOXYPHENYL)-5-PYRIDIN-4-YL-4H-1,2,4-TRIAZOLE-3-THIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-isonicotinoyl-N-(4-methoxyphenyl)hydrazine-1-carbothioamide (97195-92-1) → 4-(4-methoxyphenyl)-3-(pyridin-4-yl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazole (109220-26-0)

Guidance literature:

With sodium hydroxide; In water; at 70 ℃; for 2h;

DOI:10.1016/j.bioorg.2021.105270

Reference yield: 90.0%

2-isonicotinoyl-N-(4-methoxyphenyl)hydrazine-1-carbothioamide (97195-92-1) → 4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol (109220-26-0)

Guidance literature:

With sodium hydroxide; Reflux;

DOI:10.14233/ajchem.2017.20481

Reference yield:

isoniazid (54-85-3,7640-37-1) + 4-Methoxyphenyl isothiocyanate (2284-20-0) → 4-(4-methoxyphenyl)-3-(pyridin-4-yl)-5-sulfanylidene-4,5-dihydro-1H-1,2,4-triazole (109220-26-0)

Guidance literature:

isoniazid; 4-Methoxyphenyl isothiocyanate; In methanol; ethanol; at 20 ℃; for 2h;

With sodium hydroxide; at 70 ℃; for 4h;

upstream raw materials:

2-isonicotinoyl-N-(4-methoxyphenyl)hydrazine-1-carbothioamide

isoniazid

4-methoxy-aniline

4-Methoxyphenyl isothiocyanate

Downstream raw materials:

1-(4-fluorophenyl)-2-{[4-(4-methoxyphenyl)-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl]thio}ethanone

1-(2,4-dichlorophenyl)-2-{[4-(4-methoxyphenyl)-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl]thio}ethanone

1-(4-chlorophenyl)-2-{[4-(4-methoxyphenyl)-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl]thio}ethanone

1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[4-(4-methoxyphenyl)-5-pyridin-4-yl-4H-1,2,4-triazol-3-yl]thio}ethanone