Technology Process of [(2R,3R,4S,5S,6R)-4-Azido-2,5-dimethoxy-6-(4-methoxy-benzyloxymethyl)-tetrahydro-pyran-3-yloxy]-acetic acid methyl ester
There total 7 articles about [(2R,3R,4S,5S,6R)-4-Azido-2,5-dimethoxy-6-(4-methoxy-benzyloxymethyl)-tetrahydro-pyran-3-yloxy]-acetic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 68 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 4 h
2: 80 percent / Ag2O; KI / dimethylformamide / 16 h
3: 22 percent / NaBH3CN; Me3SiCl; 3 Angstroem molecular sieves / acetonitrile / 4 h
4: Ag2O / dimethylformamide / 16 h
With
chloro-trimethyl-silane; 3 A molecular sieve; sodium cyanoborohydride; toluene-4-sulfonic acid; potassium iodide; silver(l) oxide;
In
N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(03)00384-6
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Me3SiBr; BiBr3 / CH2Cl2 / 4 h
2: Ag2O; CaSO4 / CH2Cl2 / 1 h
3: MeONa; MeOH / 4 h
4: 68 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 4 h
5: 80 percent / Ag2O; KI / dimethylformamide / 16 h
6: 22 percent / NaBH3CN; Me3SiCl; 3 Angstroem molecular sieves / acetonitrile / 4 h
7: Ag2O / dimethylformamide / 16 h
With
methanol; calcium sulfate; chloro-trimethyl-silane; bismuth(III) bromide; trimethylsilyl bromide; 3 A molecular sieve; sodium methylate; sodium cyanoborohydride; toluene-4-sulfonic acid; potassium iodide; silver(l) oxide;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(03)00384-6
- Guidance literature:
-
Multi-step reaction with 6 steps
1: Ag2O; CaSO4 / CH2Cl2 / 1 h
2: MeONa; MeOH / 4 h
3: 68 percent / p-toluenesulfonic acid monohydrate / dimethylformamide / 4 h
4: 80 percent / Ag2O; KI / dimethylformamide / 16 h
5: 22 percent / NaBH3CN; Me3SiCl; 3 Angstroem molecular sieves / acetonitrile / 4 h
6: Ag2O / dimethylformamide / 16 h
With
methanol; calcium sulfate; chloro-trimethyl-silane; 3 A molecular sieve; sodium methylate; sodium cyanoborohydride; toluene-4-sulfonic acid; potassium iodide; silver(l) oxide;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0960-894X(03)00384-6
