1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Base Information

Chemical Name:1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole
CAS No.:137016-74-1
Molecular Formula:C₇₀H₈₈Cl₄N₅O₁₃PSi₃
Molecular Weight:1464.54
Hs Code.:

1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-<O<sup>P</sup>-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

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Chemical Property of 1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

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Technology Process of 1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

There total 11 articles about 1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 137016-61-6
5,6-dichloro-1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

: 137016-65-0
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazole 2'-<2-(4-nitrophenyl)ethyl triethylammonium phosphate>

: 137016-74-1,137120-01-5
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Guidance literature:: With 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; In pyridine; for 48h; Ambient temperature;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 6478-73-5
5,6-dichlorobenzimidazole

: 137016-74-1,137120-01-5
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

6: 1) 4-nitrobenzaldoxime, H₂O / 1) dioxane, r.t., 20 min, 2) 1.5 h

7: 48 percent / N-methylimidazole, 2,4,6-tri-isopropylbenzenesulfonyl chloride / pyridine / 48 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; water; sodium methylate; toluene-4-sulfonic acid; 4-nitrobenzaldehyde oxime; In pyridine; methanol;
DOI:10.1016/0008-6215(92)84178-U

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 137016-74-1,137120-01-5
1-(3-O-tert-butyldimethylsilyl-5-O-p-methoxytrityl-β-D-ribofuranosyl)-5,6-dichlorobenzimidazolyl-(2'-P-<2-(4-nitrophenyl)ethyl>>->5')-5,6-dichloro 1-(2,3-di-O-tert-butyldimethylsilyl-β-D-ribofuranosyl)benzimidazole

Guidance literature:: Multi-step reaction with 7 steps

1: 51 percent / p-TsOH / 1 h / 170 - 180 °C / 20 Torr

2: NaOMe / methanol

3: 87 percent / pyridine / Ambient temperature

4: 35 percent / pyridine / 18 h / Ambient temperature

6: 1) 4-nitrobenzaldoxime, H₂O / 1) dioxane, r.t., 20 min, 2) 1.5 h

7: 48 percent / N-methylimidazole, 2,4,6-tri-isopropylbenzenesulfonyl chloride / pyridine / 48 h / Ambient temperature

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; water; sodium methylate; toluene-4-sulfonic acid; 4-nitrobenzaldehyde oxime; In pyridine; methanol;
DOI:10.1016/0008-6215(92)84178-U