3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride

Base Information

• Chemical Name: 3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride
• CAS No.: 1333383-62-2
• Molecular Formula: C₃₃H₅₁N₂O₅*Cl
• Molecular Weight: 591.231
• Mol file: 1333383-62-2.mol

Synonyms:

Chemical Property of 3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride

There total 9 articles about 3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl N-[1,1-dimethylethoxycarbonyl]-N-[9-[3-(3-pyridinyl)propoxy]nonyl]-β-alaninate (1333383-61-1) + benzyl chloride (100-44-7) → 3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride (1333383-62-2)

Guidance literature:

at 90 ℃; for 2h;

DOI:10.1111/j.1747-0285.2011.01154.x

Reference yield:

9-azidononyl methanesulfonate (1333383-54-2) → 3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride (1333383-62-2)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrabutylammomium bromide; sodium hydroxide / diethyl ether; water / 72 h / 25 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / Inert atmosphere; Cooling with ice

3: toluene / 22 h / Reflux

4: dichloromethane / 22 h / 25 °C

5: 2 h / 90 °C

With lithium aluminium tetrahydride; tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;

DOI:10.1111/j.1747-0285.2011.01154.x

Reference yield:

3-(3-(9-azidononyloxy)propyl)pyridine (1333383-56-4) → 3-[3-[9-[(1,1-dimethylethoxycarbonyl)(3-methoxy-3- oxopropylamino)]nonyloxy]propyl]-1-(phenylmethyl)-pyridinium chloride (1333383-62-2)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / Inert atmosphere; Cooling with ice

2: toluene / 22 h / Reflux

3: dichloromethane / 22 h / 25 °C

4: 2 h / 90 °C

With lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1111/j.1747-0285.2011.01154.x

upstream raw materials:

9-(3-pyridinylpropoxy)-1-nonanamine

methyl N-[9-[3-(3-pyridinyl)propoxy]nonyl]-β-alaninate

methyl N-[1,1-dimethylethoxycarbonyl]-N-[9-[3-(3-pyridinyl)propoxy]nonyl]-β-alaninate

benzyl chloride