Technology Process of C24H30ClNO5
There total 11 articles about C24H30ClNO5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
rac-3-bromocyclohexene;
With
zinc;
In
tetrahydrofuran;
at 23 ℃;
for 18h;
Inert atmosphere;
C18H20ClNO5;
In
tetrahydrofuran;
at -78 - -20 ℃;
for 1.5h;
Inert atmosphere;
With
water;
In
tetrahydrofuran;
Inert atmosphere;
DOI:10.1021/jo101638r
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 2-hydroxypyridin / 1,2-dichloro-ethane / 53 °C / Microwave irradiation; Inert atmosphere
2.1: morpholine; tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / -5 °C / Inert atmosphere
3.1: 4-pyrrolidin-1-ylpyridine; p-toluenesulfonyl chloride / -5 °C / Inert atmosphere
4.1: palladium on carbon; hydrogen / tetrahydrofuran / 12 h / 23 °C
5.1: dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide; toluene / 6 h / 23 °C / Inert atmosphere
6.1: zinc / tetrahydrofuran / 18 h / 23 °C / Inert atmosphere
6.2: 1.5 h / -78 - -20 °C / Inert atmosphere
6.3: Inert atmosphere
With
morpholine; 2-hydroxypyridin; dichloro-acetic acid; tetrakis(triphenylphosphine) palladium(0); palladium on carbon; hydrogen; 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; zinc;
In
tetrahydrofuran; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
5.1: Moffatt oxidation;
DOI:10.1021/jo101638r
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-pyrrolidin-1-ylpyridine; p-toluenesulfonyl chloride / -5 °C / Inert atmosphere
2.1: palladium on carbon; hydrogen / tetrahydrofuran / 12 h / 23 °C
3.1: dichloro-acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dimethyl sulfoxide; toluene / 6 h / 23 °C / Inert atmosphere
4.1: zinc / tetrahydrofuran / 18 h / 23 °C / Inert atmosphere
4.2: 1.5 h / -78 - -20 °C / Inert atmosphere
4.3: Inert atmosphere
With
dichloro-acetic acid; palladium on carbon; hydrogen; 4-pyrrolidin-1-ylpyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; p-toluenesulfonyl chloride; zinc;
In
tetrahydrofuran; dimethyl sulfoxide; toluene;
3.1: Moffatt oxidation;
DOI:10.1021/jo101638r
