(((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

Base Information

Chemical Name:(((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane
CAS No.:1333237-45-8
Molecular Formula:C₂₆H₄₁Cl₃O₅Si
Molecular Weight:568.053
Hs Code.:

(((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

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Chemical Property of (((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

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Technology Process of (((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

There total 3 articles about (((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333237-44-7
(2S,3S)-6-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-1-((tert-butyldimethylsilyl)oxy)-3,6,6-trichlorohexan-2-ol

: 1333237-45-8
(((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/anie.201102521

Reference yield:

: (3-(3-((4R,5S,6S)-6-(benzyloxymethyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methanol

: 1333237-45-8
(((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: triisopropoxytitanium(IV) chloride / hexane; benzene / 14 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; triisopropoxytitanium(IV) chloride; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; benzene;
DOI:10.1002/anie.201102521

Reference yield:

: 1333237-36-7
(2S,3S)-6-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,6,6-trichlorohexane-1,2-diol

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1333237-45-8
(((2S,3R)-3-(3-((4R,5S,6S)-6-((benzyloxy)methyl)-5-chloro-2,2-dimethyl-1,3-dioxan-4-yl)-3,3-dichloropropyl)oxiran-2-yl)methoxy)(tert-butyl)dimethylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 0 - 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/anie.201102521