C₂₇H₃₆BrNO₃

Base Information

• Chemical Name: C₂₇H₃₆BrNO₃
• CAS No.: 1552303-62-4
• Molecular Formula: C₂₇H₃₆BrNO₃
• Molecular Weight: 502.492
• Mol file: 1552303-62-4.mol

Synonyms:

Chemical Property of C₂₇H₃₆BrNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₆BrNO₃

There total 5 articles about C₂₇H₃₆BrNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-(2-methoxyphenyl)piperidine (58333-75-8) + methyl isopropyl(3-bromopropyl)-4-bromophenylacetate (1061284-73-8) → C27H36BrNO3 (1552303-62-4)

Guidance literature:

With triethylamine; sodium iodide; In acetonitrile; Reflux;

DOI:10.1016/j.bmcl.2013.12.078

Reference yield:

1,2,3,6-tetrahydro-4-(2-methoxyphenyl)pyridine (154422-95-4) → C27H36BrNO3 (1552303-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C

2: triethylamine; sodium iodide / acetonitrile / Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; sodium iodide; In ethanol; acetonitrile;

DOI:10.1016/j.bmcl.2013.12.078

Reference yield:

2-methoxyphenylmagnesium bromide (16750-63-3) → C27H36BrNO3 (1552303-62-4)

Guidance literature:

Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / 0 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / Reflux

3: palladium 10% on activated carbon; hydrogen / ethanol / 5 h / 20 °C

4: triethylamine; sodium iodide / acetonitrile / Reflux

With palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 1: |Grignard Reaction;

DOI:10.1016/j.bmcl.2013.12.078

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

1-t-Butoxycarbonyl-4-hydroxy-4-(2-methoxyphenyl)piperidine

1,2,3,6-tetrahydro-4-(2-methoxyphenyl)pyridine

4-(2-methoxyphenyl)piperidine