3-(benzyl)-6-chloro-7-hydroxy-4-methyl-coumarin

Base Information

Chemical Name:3-(benzyl)-6-chloro-7-hydroxy-4-methyl-coumarin
CAS No.:109650-11-5
Molecular Formula:C17H13ClO3
Molecular Weight:300.73600
Hs Code.:
Mol file:109650-11-5.mol

Synonyms:6-Chlor-7-hydroxy-4-methyl-3-benzyl-cumarin;3-benzyl-6-chloro-7-hydroxy-4-methyl-coumarin;3-Benzyl-6-chlor-7-hydroxy-4-methyl-cumarin;3-Benzyl-6-chloro-7-hydroxy-4-methyl-chromen-2-one;

Suppliers and Price of 3-(benzyl)-6-chloro-7-hydroxy-4-methyl-coumarin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-Benzyl-6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one
1g
$ 150.00

Matrix Scientific
3-Benzyl-6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one
0.500g
$ 120.00

Total 2 raw suppliers

Chemical Property of 3-(benzyl)-6-chloro-7-hydroxy-4-methyl-coumarin

Chemical Property:

Melting Point:261 - 263 °C (ethanol)
Boiling Point:493.2±45.0 °C(Predicted)
PKA:6.67±0.20(Predicted)
PSA：50.44000
Density:1.356±0.06 g/cm3(Predicted)
LogP:4.05120

Purity/Quality:

99% ^*data from raw suppliers

3-Benzyl-6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(benzyl)-6-chloro-7-hydroxy-4-methyl-coumarin

There total 3 articles about 3-(benzyl)-6-chloro-7-hydroxy-4-methyl-coumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.5%

: 95-88-5
4-Chlororesorcinol

: 620-79-1
Ethyl 2-benzylacetoacetate

: 109650-11-5
3-benzyl-6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one

Guidance literature:: With sulfuric acid; at 20 ℃; for 12h;
DOI:10.3390/molecules18056057

Reference yield:

: 100-39-0
benzyl bromide

: 109650-11-5
3-benzyl-6-chloro-7-hydroxy-4-methyl-2H-chromen-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 60 °C / Inert atmosphere

2.1: sulfuric acid / 12 h / 20 °C

With sulfuric acid; sodium hydride; In tetrahydrofuran; 2.1: |Pechmann Condensation;
DOI:10.3390/molecules18056057