2-(2-methylphenyl)-benzimidazole

Base Information

• Chemical Name: 2-(2-methylphenyl)-benzimidazole
• CAS No.: 109744-85-6
• Molecular Formula: C20H16N2
• Molecular Weight: 284.36
• Mol file: 109744-85-6.mol

Synonyms:N-phenyl-2-(2-methylphenyl)benzimidazole;1-Phenyl-2-o-tolyl-1H-benzoimidazole;1-phenyl-2-(2-methylphenyl)benzimidazole;

Chemical Property of 2-(2-methylphenyl)-benzimidazole

Chemical Property:

• PSA: 17.82000
• LogP: 5.00090

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-methylphenyl)-benzimidazole

There total 4 articles about 2-(2-methylphenyl)-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ortho-methylbenzoic acid (118-90-1) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(2-methylphenyl)-1-phenyl-1H-benzimidazole (109744-85-6)

Guidance literature:

With trifluoromethylsulfonic anhydride; Triphenylphosphine oxide; In 1,2-dichloro-ethane; at 25 ℃; for 0.5h;

DOI:10.1021/jo00266a028

Reference yield: 67.0%

2-methylphenyl aldehyde (529-20-4) + N-phenyl-1,2-benzenediamine (534-85-0) → 2-(2-methylphenyl)-1-phenyl-1H-benzimidazole (109744-85-6)

Guidance literature:

With sodium metabisulfite; In N,N-dimethyl-formamide; at 100 ℃; for 0.1h; Microwave irradiation;

DOI:10.1002/jhet.1058

Reference yield: 45.0%

N-phenyl-2-(2-methylphenyl)formamidine (32622-24-5) + phenylboronic acid (98-80-6) → 2-(2-methylphenyl)-1-phenyl-1H-benzimidazole (109744-85-6)

Guidance literature:

N-phenyl-2-(2-methylphenyl)formamidine; phenylboronic acid; With copper(II) acetate monohydrate; sodium pivalate; In N,N-dimethyl-formamide; at 50 ℃;

With oxygen; In N,N-dimethyl-formamide; at 120 ℃;

DOI:10.1021/ol3028847

upstream raw materials:

ortho-methylbenzoic acid

N-phenyl-1,2-benzenediamine

ortho-toluoyl chloride

2-methylphenyl aldehyde