ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4

Base Information

• Chemical Name: ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4
• CAS No.: 68672-67-3
• Molecular Formula: C₄₆H₅₁N₅O₉S₂
• Molecular Weight: 882.071
• Mol file: 68672-67-3.mol

Synonyms:

Chemical Property of ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4

There total 5 articles about ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

(Z)-2-(1-t-butoxycarbonyl-1-methylethoxyimino)-2-[2-(triphenylmethylamino)thiazol-4-yl]acetic acid (68672-66-2) + 7-Aminocephalosporanic acid t-butyl ester (6187-87-7) → ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4 (68672-67-3)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; for 2h;

Reference yield:

tert-butyl bromoisobutyrate (23877-12-5) → ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4 (68672-67-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / potassium carbonate / dimethylformamide / 1.5 h / Ambient temperature

2: 61 percent / potassium hydroxide / methanol / 2 h / Heating

3: 20 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h

With potassium hydroxide; potassium carbonate; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

imino-2 Z (tritylamino-2 thiazolyl-4)-2 acetate d'ethyle (68672-65-1) → ester de tert-butylique de l'acide (acetoxy methyl)-3(<<-imino-2 Z (tritylamino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4 (68672-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 61 percent / potassium hydroxide / methanol / 2 h / Heating

2: 20 percent / dicyclohexylcarbodiimide / CH₂Cl₂ / 2 h

With potassium hydroxide; dicyclohexyl-carbodiimide; In methanol; dichloromethane;

upstream raw materials:

(Z)-2-(1-t-butoxycarbonyl-1-methylethoxyimino)-2-[2-(triphenylmethylamino)thiazol-4-yl]acetic acid

7-Aminocephalosporanic acid t-butyl ester

tert-butyl bromoisobutyrate

imino-2 Z (tritylamino-2 thiazolyl-4)-2 acetate d'ethyle

Downstream raw materials:

acide (acetoxy methyl)-3(<<(carboxy-1 methyl-1 ethoxy)-imino-2 Z (amino-2 thiazolyl-4)-2>-acetyl>-amino)-7 β cepheme-3 carboxylique-4

Refernces